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【文摘发布】衰老、肥胖与热量控制
Author：Luigi Fontana, MD, PhD; Samuel Klein, MD
Resource: JAMA. 2007;297:986-994.
Abstract：
CONTEXT: 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Title：Aging, Adiposity, and Calorie Restriction
题目：衰老、肥胖与热量控制
Author：Luigi Fontana, MD, PhD; Samuel Klein, MD
作者：Luigi Fontana, MD, PhD; Samuel Klein, MD
Resource: JAMA. 2007;297:986-994.
来源：JAMA. 2007;297:986-994
Abstract：
摘要：
CONTEXT: Excessive calorie intake and subsequent obesity increases the risk of developing chronic disease and decreases life expectancy. In rodent models, calorie restriction with adequate nutrient intake decreases the risk of developing chronic disease and extends maximum life span.
背景：过多的热量摄入和继发的肥胖能够增加慢性疾病发生的危险，减少预期寿命。在动物模型中，摄取足够的营养并且限制热量的摄入能够减少慢性疾病发生的危险，并能延长寿命。
OBJECTIVE: To evaluate the physiological and clinical implications of calorie restriction with adequate nutrient intake.
目的：为了评估在摄取足够的营养时限制热量摄入的生理和临床意义。
EVIDENCE ACQUISITION: Search of PubMed (1966-December 2006) using terms encompassing various aspects of calorie restriction, dietary restriction, aging, longevity, life span, adiposity, and obesity; hand search of journals that focus on obesity, geriatrics, or aging; and search of reference lists of pertinent research and review articles and books. Reviewed reports (both basic science and clinical) included epidemiologic studies, case-control studies, and randomized controlled trials, with quality of data assessed by taking into account publication in a peer-reviewed journal, number of animals or individuals studied, objectivity of measurements, and techniques used to minimize bias.
证据采集：使用包含热量限制、饮食限制、年龄、寿命、生存期、肥胖、肥胖症等的不同方面的术语，在PubMed上搜索1966年至2006年12月的文献。人工搜索关于肥胖、老年病学或衰老的杂志；搜索有关研究、综述和书籍的参考文献列表。回顾基础科学和临床科学的报告 包括流行病学研究、病例对照研究和随机对照研究， 数据的质量根据在同级平审的杂志上的文章、研究样本的数量、测量方法的客观性和减少误差的技术来评估。
EVIDENCE SYNTHESIS: It is not known whether calorie restriction extends maximum life span or life expectancy in lean humans. However, calorie restriction in adult men and women causes many of the same metabolic adaptations that occur in calorie-restricted rodents and monkeys, including decreased metabolic, hormonal, and inflammatory risk factors for diabetes, cardiovascular disease, and possibly cancer. Excessive calorie restriction causes malnutrition and has adverse clinical effects.
证据分析：还不知道限制热量的摄入能最大的延长瘦人的生命或预期寿命。尽管如此，限制成年男性和女性热量的摄入能引起许多代谢适应，就像在限制热量摄入的鼠和猴中发生的一样，其包括代谢和荷尔蒙分泌，糖尿病的炎性易感因素、心血管疾病以及癌症发生率的降低。过多的限制热量摄入可以造成营养不良，产生不利的临床效应。
CONCLUSIONS: Calorie restriction in adult men and women causes beneficial metabolic, hormonal, and functional changes, but the precise amount of calorie intake or body fat mass associated with optimal health and maximum longevity in humans is not known. In addition, it is possible that even moderate calorie restriction may be harmful in specific patient populations, such as lean persons who have minimal amounts of body fat.
结论：限制成年男女热量的摄入有利于代谢、内分泌和机能的改变，但是维持人类身体健康、延长生命的准确的热量摄入量或体脂量还不请楚。此外，仅仅轻度的限制热量摄入对一些特殊疼病患者有害，例如拥有最少体脂量的瘦人。
PMID: 17341713
编译：[标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-06-02 17:11
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