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【文摘发布】定量免疫化学法的大便潜血试验筛
Author:Levi Z, Rozen P, Hazazi R, Vilkin A, Waked A, Maoz E, Birkenfeld S, Leshno M, Niv Y.
Resource:Ann Intern Med. 2007 Feb 20;146(4):244-55
Abstract:
BACKGROUND: Guaiac-based fecal occult blood tests (FOBTs) for colorectal cancer screening are not specific for human hemoglobin and have low sensitivity. Automated-development, immunochemical FOBT is quality-controlled, is specific for human hemoglobin, and does not require diet restriction. OBJECTIVES: To measure the sensitivity and specificity of quantitative immunochemical fecal hemoglobin measurements for detection of cancer and advanced adenoma in patients undergoing colonoscopy, to determine fecal hemoglobin thresholds that give the highest posttest probability for neoplasia, and to determine the number of immunochemical FOBTs needed. DESIGN: Prospective, cross-sectional study. SETTING: Ambulatory endoscopy services of the main health medical organization in Tel Aviv, Israel. PARTICIPANTS: 1000 consecutive ambulatory patients--some asymptomatic but at increased risk for colorectal neoplasia and some symptomatic--who were undergoing elective colonoscopy and volunteered to prepare immunochemical FOBTs. INTERVENTION: The hemoglobin content of 3 bowel movements was measured, and the highest value was compared with colonoscopy findings. MEASUREMENTS: Sensitivity, specificity, predictive values, likelihood ratios, and 95% CIs of fecal hemoglobin measurements for clinically significant neoplasia, their relationship to the amount of fecal hemoglobin measured, and the number of immunochemical FOBTs performed. RESULTS: Colonoscopy identified clinically significant neoplasia in 91 patients (cancer in 17 patients and advanced adenomas in 74 patients). Using 3 immunochemical FOBTs and a hemoglobin threshold of 75 ng/mL of buffer, sensitivity and specificity were 94.1% (95% CI, 82.9% to 100.0%) and 87.5% (CI, 85.4% to 89.6%), respectively, for cancer and 67% (CI, 57.4% to 76.7%) and 91.4% (CI, 89.6% to 93.2%), respectively, for any clinically significant neoplasia. LIMITATIONS: The fecal sampling method is standardized, but the sample size depends on fecal consistency. Some patients were tested while discontinuing aspirin and anticoagulant therapies. Study patients were at increased risk, and results might not apply to average-risk populations. CONCLUSIONS: Quantitative immunochemical FOBT has good sensitivity and specificity for detection of clinically significant neoplasia. Test performance in screening average-risk populations is not known.
PMID:17310048 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Title: A quantitative immunochemical fecal occult blood test for colorectal neoplasia.
一种定量免疫化学法测粪便潜血实验被用于筛选结直肠肿瘤
Author:Levi Z, Rozen P, Hazazi R, Vilkin A, Waked A, Maoz E, Birkenfeld S, Leshno M, Niv Y.
作者:Levi Z, Rozen P, Hazazi R, Vilkin A, Waked A, Maoz E, Birkenfeld S, Leshno M, Niv Y.
Resource:Ann Intern Med. 2007 Feb 20;146(4):244-55
来源：《内科学年鉴》2007－2－20；146(4):244-55
Abstract:
摘要：
BACKGROUND: Guaiac-based fecal occult blood tests (FOBTs) for colorectal cancer screening are not specific for human hemoglobin and have low sensitivity. Automated-development, immunochemical FOBT is quality-controlled, is specific for human hemoglobin, and does not require diet restriction.
背景：以愈创木脂为试剂的粪便潜血实验(FOBTs)用于结直肠癌的筛查中，不仅对人血红蛋白特异性不高而且敏感性也很低。随着自动化的发展，免疫化学法的FOBT是有质量控制的，而且对于人血红蛋白特异性比较高，还不需要限制饮食。
OBJECTIVES: To measure the sensitivity and specificity of quantitative immunochemical fecal hemoglobin measurements for detection of cancer and advanced adenoma in patients undergoing colonoscopy, to determine fecal hemoglobin thresholds that give the highest posttest probability for neoplasia, and to determine the number of immunochemical FOBTs needed.
目的：检测定量免疫化学法的粪便血红蛋白测量实验的敏感性和特异性，而这个实验的用途在于发现那些正在行结肠镜检查的病人的癌和早期腺瘤的存在。确定能够提示实验后最有可能存在肿瘤的粪便血红蛋白阈值，确定需要进行的免疫化学法的FOBTs的次数。
DESIGN: Prospective, cross-sectional study.
设计：前瞻性的横向研究。
SETTING: Ambulatory endoscopy services of the main health medical organization in Tel Aviv, Israel.
环境：以色列特拉维夫的主要的健康医疗机构的不住院的内镜检查机构。
PARTICIPANTS: 1000 consecutive ambulatory patients--some asymptomatic but at increased risk for colorectal neoplasia and some symptomatic--who were undergoing elective colonoscopy and volunteered to prepare immunochemical FOBTs.
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作者:admin@医学,生命科学 2011-06-02 05:11
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