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【medical-news】室性早搏可预测冠心病死亡率
29 December 2006
People with ventricular premature complexes (VPCs) on electrocardiography are twice as likely to die of coronary heart disease (CHD) as people without VPCs, irrespective of whether they already show evidence of CHD, US researchers report.
As a consequence, they say, a clinical finding of VPCs even in apparently healthy patients "may warrant heightened awareness of and attention to cardiovascular risk management."
Ross Simpson (University of North Carolina at Chapel Hill) and colleagues conducted a prospective analysis of the population-based Atherosclerosis Risk in Communities (ARIC) study of 15,070 patients aged between 45 and 64 years.
They wanted to evaluate the association between VPCs and CHD risk among people with and without established CHD, given that VPCs are more likely to appear in patients with established CHD.
VPCs were identified on a single 2-minute electrocardiogram in 940 (6.2%) participants.
Over a 10-year follow-up period, people with VPCs had more than 3 times the rate of CHD mortality of those without VPCs, at 7.8% versus 2.1%.
After adjustment for cardiovascular risk factors and therapy, participants with VPCs had twice the risk of CHD mortality of those without them, an increase which remained constant when considering those without CHD at baseline.
"The presence of VPCs may place patients in higher risk categories and should lead physicians to recommend more aggressive treatment of modifiable risk factors for CHD such as blood pressure, cholesterol, and smoking," the authors write in the American Journal of Cardiology.
They conclude: "Aggressive management of cardiovascular risk factors, especially hypertension, would seem to be a prudent clinical response to a finding of VPCs on electrocardiography."
Am J Cardiol 2006; 98: 1609-1612
http://www.incirculation.net/NewsItem/Ventricular-premature-complexes-predict-CHD-mortal.aspx
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作者:admin@医学,生命科学 2011-04-07 05:14
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