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【文摘发布】器官移植后妊娠：英国移植妊娠登
Source:Transplantation. 83(10):1301-1307, May 27, 2007.
Authors:Sibanda, Nokuthaba ; Briggs, J Douglas ; Davison, John M. ; Johnson, Rachel J; Rudge, Chris J
Abstract:Background. Maternal and fetal complications in pregnancies after renal transplantation have been highlighted in several reports, but information on their main predisposing factors is limited. The U.K. Transplant Pregnancy Registry was established in 1997 to obtain detailed information on pregnancies in female organ transplant recipients across the U.K.
Methods. For each female kidney, liver, or cardiothoracic organ transplant recipient who had had a recent pregnancy, data on maternal and fetal factors and pregnancy outcomes were collected using forms completed by their transplant follow-up and obstetric units. For kidney transplant recipients, the factors that influence pregnancy outcome were studied using logistic regression, and the effect of pregnancy on graft function was analyzed.
Results. There were live births in 83%, 69%, and 79% of pregnancies in cardiothoracic organ, liver, and kidney recipients, respectively. In 50% of live births from renal patients, delivery was preterm (<37 weeks), with 83% of the preterm infants delivered via caesarean. Preterm delivery was associated with maternal drug-treated hypertension and impaired renal function. A matched case-control study showed no evidence of increased renal allograft loss after pregnancy. A univariate survival analysis, however, suggested an association between drug-treated hypertension during pregnancy and poorer postpregnancy graft survival. In patients with prepregnancy serum creatinine (SCr) >150 [mu]mol/L, a trend toward increased postpregnancy SCr was identified.
Conclusions. Pregnancy is likely to end in a live birth in a majority of organ transplant recipients. In patients with greater prepregnancy SCr and/or drug-treated hypertension during pregnancy, however, subsequent renal function may be adversely affected. 本人认领此文. 如在48小时内未能提交译文, 其他战友自由认领. Title：Pregnancy After Organ Transplantation: A Report From the U.K. Transplant Pregnancy Registry.[
题目：器官移植后妊娠：英国移植妊娠登记处的报告
Source:Transplantation. 83(10):1301-1307, May 27, 2007.
来源：《移植学》. 83(10):1301-1307, May 27, 2007.
Authors:Sibanda, Nokuthaba ; Briggs, J Douglas ; Davison, John M. ; Johnson, Rachel J; Rudge, Chris J
作者：Sibanda, Nokuthaba ; Briggs, J Douglas ; Davison, John M. ; Johnson, Rachel J; Rudge, Chris J
Abstract:摘要
Background. Maternal and fetal complications in pregnancies after renal transplantation have been highlighted in several reports, but information on their main predisposing factors is limited. The U.K. Transplant Pregnancy Registry was established in 1997 to obtain detailed information on pregnancies in female organ transplant recipients across the U.K.
背景：肾移植后妊娠的母婴并发症已得到数项报告的重视，但与之相关的影响因素方面的资料却为数不多。英国移植妊娠登记处建立于1997年，其作用是收集全英国接受器官移植的女性妊娠的详细资料。
Methods. For each female kidney, liver, or cardiothoracic organ transplant recipient who had had a recent pregnancy, data on maternal and fetal factors and pregnancy outcomes were collected using forms completed by their transplant follow-up and obstetric units.
方法：对每一位接受肾脏、肝脏或心胸器官移植并在近期妊娠的女性，由移植随访（小组）和产科人员收集其母婴因素与妊娠结局的相关资料并填充于表格。
For kidney transplant recipients, the factors that influence pregnancy outcome were studied using logistic regression, and the effect of pregnancy on graft function was analyzed.
对于接受肾移植的患者，用回归分析方法对其影响妊娠结局的因素进行研究，同时分析了妊娠对移植肾功能的影响。
Results. There were live births in 83%, 69%, and 79% of pregnancies in cardiothoracic organ, liver, and kidney recipients, respectively.
结果：接受心胸器官移植、肝移植和肾移植的妊娠活产率分别为83%、69%和79%。
In 50% of live births from renal patients, delivery was preterm (<37 weeks), with 83% of the preterm infants delivered via caesarean.
肾移植患者中的50%活产婴儿为早产（<37周），其中83%的早产婴儿是通过剖腹产分娩。
Preterm delivery was associated with maternal drug-treated hypertension and impaired renal function. A matched case-control study showed no evidence of increased renal allograft loss after pregnancy.
早产与母亲服药治疗高血压及肾功能损害有关。一项配对病例对照研究发现没有证据表明妊娠会增加移植肾失功发生率。
A univariate survival analysis, however, suggested an association between drug-treated hypertension during pregnancy and poorer postpregnancy graft survival.
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作者:admin@医学,生命科学 2011-02-18 17:12
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