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【文摘发布】供受体的因素影响到肝移植病人G
Author:Chan EY, Larson AM, Gernsheimer TB, Kowdley KV, Carithers RL Jr, Reyes JD, Perkins JD
Source:Liver Transpl. 2007 Mar 29;13(4):516-522
IF:4.447(2005)
Acute cellular graft-vs.-host disease (GVHD) following liver transplantation has an incidence of 1 to 2% and a mortality rate of 85%. Our aim was to identify a patient population at high risk for developing GVHD using a large clinical database to study both recipient and donor factors. We compared our liver transplant patients who developed GVHD to those that did not for recipient and donor factors and combinations of factors. For 2003-2004 we had 205 first-time liver transplant patients surviving >30 days. From this group, 4 (1.9%) developed GVHD. Compared to the control group, there were no significant differences in recipient age, recipient gender, donor age, donor gender, total ischemia time, donor-recipient human leukocyte antigen (HLA) mismatch, or donor-recipient age difference. Percentages of liver disease etiologies among the patients who developed GVHD were as follows: 16% (1/6) autoimmune hepatitis (AIH) (P = 0.003), 5.6% (3/54) alcoholic liver disease (ALD) (P = 0.057), and 7.1% (3/42) hepatocellular carcinoma (HCC) (P = 0.026). The incidence of GVHD in patients with glucose intolerance (either Type I or Type II diabetes mellitus [DM]) was significant (P = 0.022). Focusing on patients only with high-risk factors for GVHD during the years 2003-2005, we had 19 such patients. Four of these high-risk patients developed GVHD. Three of these 4 patients had received a donor liver with steatosis of degree >/=mild compared to only 2 of the 15 high-risk patients who did not develop GVHD (P = 0.037). In conclusion, we have identified liver transplant patients with AIH or the combination of ALD, HCC, and glucose intolerance who receive a steatotic donor liver as being at high risk for developing GVHD 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Title:Recipient and donor factors influence the incidence of graft-vs.-host disease in liver transplant patients
标题：供受体的因素影响到肝移植病人GVHD的发生率
Author:Chan EY, Larson AM, Gernsheimer TB, Kowdley KV, Carithers RL Jr, Reyes JD, Perkins JD
作者：Chan EY, Larson AM, Gernsheimer TB, Kowdley KV, Carithers RL Jr, Reyes JD, Perkins JD
Source:Liver Transpl. 2007 Mar 29;13(4):516-522
文章来源：肝脏移植. 2007.3.29; 13(4):516-522
IF:4.447(2005)
影响因子：4.447(2005)
Acute cellular graft-vs.-host disease (GVHD) following liver transplantation has an incidence of 1 to 2% and a mortality rate of 85%.
肝脏移植后急性细胞移植物抗宿主病（GVHD）的发生率为1％到2%，且死亡率为85%。
Our aim was to identify a patient population at high risk for developing GVHD using a large clinical database to study both recipient and donor factors.
我们的目地是通过使用大量临床数据库来研究受体和供体因素，以此确定GVHD发病高风险人群。
We compared our liver transplant patients who developed GVHD to those that did not for recipient and donor factors and combinations of factors.
我们比较发生GVHD的肝移植患者与未发生GVHD患者的受体和供体因素及混合因素。
For 2003-2004 we had 205 first-time liver transplant patients surviving >30 days.
2003-2004年我们有205名患者首次肝移植后存活30天以上。
From this group, 4 (1.9%) developed GVHD.
其中，4名(1.9%) 出现GVHD。
Compared to the control group, there were no significant differences in recipient age, recipient gender, donor age, donor gender, total ischemia time, donor-recipient human leukocyte antigen (HLA) mismatch, or donor-recipient age difference.
与对照组相比，在受体年龄，受体性别，供体年龄，供体性别，总的局部缺血时间，供受体人白细胞抗原(HLA)不匹配，或者供受体年龄差异方面不存在显著差别。
Percentages of liver disease etiologies among the patients who developed GVHD were as follows: 16% (1/6) autoimmune hepatitis (AIH) (P = 0.003), 5.6% (3/54) alcoholic liver disease (ALD) (P = 0.057), and 7.1% (3/42) hepatocellular carcinoma (HCC) (P = 0.026).
出现GVHD的患者其肝脏疾病病因百分比如下：16% (1/6)为自身免疫性肝炎(AIH) (P = 0.003), 5.6% (3/54)为酒精性肝病(ALD) (P = 0.057), 7.1% (3/42)为肝细胞癌(HCC) (P = 0.026)。
The incidence of GVHD in patients with glucose intolerance (either Type I or Type II diabetes mellitus [DM]) was significant (P = 0.022).
葡萄糖耐受不良（I 或II型糖尿病）患者GVHD发病率显著(P = 0.022)。
Focusing on patients only with high-risk factors for GVHD during the years 2003-2005, we had 19 such patients. Four of these high-risk patients developed GVHD.
2003-2005间仅集中研究有GVHD高风险因素的患者，纳入19名此类患者。其中4名发生GVHD。
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作者:admin@医学,生命科学 2010-11-21 05:14
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