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【medical-news】世卫组织发起抗疟疾疫苗全球运动
Mon Dec 4, 2006 6:24am ET
By Darren Schuettler
BANGKOK (Reuters) - The World Health Organization launched a new global effort on Monday to find a vaccine against malaria, which infects up to 500 million people each year, and the donors to pay for it.
The Malaria Vaccine Technology Roadmap aims to develop and license a first generation vaccine by 2015 against the mosquito-borne disease which kills more than one million people a year, mainly African children.
"The Roadmap marks the first concerted global attempt at mapping out a shared plan of action for making a preventive malaria vaccine reality," Marie-Paule Kieny, a top WHO official, said on the sidelines of a vaccine conference in Bangkok.
Malaria is one of the world's oldest diseases, but only $79 million was invested on researching a vaccine in 2004, according to a report by the Malaria Research and Development Alliance.
That is a fraction of the money spent on finding a cure for HIV/AIDS or, more recently, the H5N1 bird flu virus which has killed 154 people since 2003 but has fanned fears of a global human pandemic.
For years, malaria was not seen as a profitable area of research, but that is changing slowly through private-public partnerships, said Zarifah Hussain Reed, a WHO expert on vaccine and immunization issues.
"The attention drives the research. That's not to say bird flu doesn't deserve the attention, but it should not be about one disease hijacking the agenda," she told reporters.
The Roadmap aims to have a first-generation vaccine by 2015 that is 50-percent effective and would last longer than one year.
It sets a goal for a second-generation vaccine by 2025 that is more than 80 percent effective and offer protection for more than four years.
The WHO said more than 30 potential vaccines were under development, but there was not enough capacity or money to test them in clinical trials, especially in countries where the disease is endemic.
To overcome these and other hurdles the Roadmap makes a series of recommendations:
* Standardize procedures for assessing vaccine candidates and use the Internet to share information between laboratories and clinics.
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* Diversify the search for a vaccine.
* Build up capacity for clinical trials in Africa and other areas where malaria is endemic.
* Secure sustainable funding and develop a regulatory strategy to speed up approval of a safe vaccine.
Malaria is caused by protozoan parasites which thrive in humans and are passed between them by female Anopheles mosquitoes.
There is no vaccine against the parasite, which has grown resistant to a number of well-known anti-malarial drugs, including chloroquine and pyrimethamine.
Artemisinin, a compound extracted from a Chinese herb, is regarded by medical experts as the best drug against malaria and the WHO recommended in 2001 it be used in combination with other drugs to slow down any development of resistance.
http://today.reuters.com/news/articlenews.aspx?type=healthNews&storyID=2006-12-04T112433Z_01_BKK265131_RTRUKOC_0_US-MALARIA.xml&WTmodLoc=HealthNewsHome_C1_%5bFeed%5d-1 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 WHO launches new drive for malaria vaccine by 2015
世界卫生组织发起抗疟疾疫苗全球行动
Mon Dec 4, 2006 6:24am ET
By Darren Schuettler
BANGKOK (Reuters) - The World Health Organization launched a new global effort on Monday to find a vaccine against malaria, which infects up to 500 million people each year, and the donors to pay for it.
曼谷（路透社）－世界卫生组织（The World Health Organization，WHO）周一发起一项新的全球行动，呼吁开发疟疾疫苗，并为此而寻求赞助商。每年有高达5亿的人口感染上疟疾。
The Malaria Vaccine Technology Roadmap aims to develop and license a first generation vaccine by 2015 against the mosquito-borne disease which kills more than one million people a year, mainly African children.
这份《疟疾疫苗技术指南》（The Malaria Vaccine Technology Roadmap）目标在2015年前开发并通过批准第一代疟疾疫苗。疟疾，这一蚊媒传播的疾病每年导致100万以上的人口死亡，而其中多数是非洲儿童。
"The Roadmap marks the first concerted global attempt at mapping out a shared plan of action for making a preventive malaria vaccine reality," Marie-Paule Kieny, a top WHO official, said on the sidelines of a vaccine conference in Bangkok.
在曼谷疟疾大会周边会议上，WHO高级官员称：“《指南》指出，第一步旨在协调全球的努力方向以制定出共同的计划来开发预防性疟疾疫苗。”
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作者:admin@医学,生命科学 2011-02-18 12:57
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