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【文摘发布】人类偏肺病毒呼吸道感染在长期使
Author: Guy Boivin,1 Gaston De Serres,2 Marie-Eve Hamelin,1 Stéphanie Côté,1 Marco Argouin,3 Geneviève Tremblay,4 Renée Maranda-Aubut,4 Chantal Sauvageau,4 Manale Ouakki,2 Nicole Boulianne,2 and Christian Couture5
Resource:Clinical Infectious Diseases 2007;44:1152-1158
Background. Human metapneumovirus (hMPV) is a newly described paramyxovirus that is mainly associated with bronchiolitis in children. We sought to describe the epidemiological, virological, and histopathological findings associated with a large outbreak of hMPV infection in a long-term care facility.
Methods. An investigation of the outbreak was performed by public health authorities, who used standardized questionnaires to collect relevant clinical information from all residents of the facility. Nasopharyngeal samples were obtained from a subset of patients who had influenza-like illnesses for testing by viral culture and reverse-transcriptase polymerase chain reaction. Lung tissue samples from a patient whose case was fatal were available for molecular, histopathological, and immunohistochemical testing.
Results. A total of 96 (27%) of 364 residents of a long-term care facility presented with respiratory or constitutional symptoms between 1 January 2006 and 15 February 2006. The attack rate in the most affected ward was 72% (31 of 43 patients), which included 4 of the 6 polymerase chain reaction–confirmed cases of hMPV infection. In contrast, viral culture results were positive for hMPV in only 2 of the 5 polymerase chain reaction–positive samples tested. The most reported diagnosis was an upper respiratory tract infection or an influenza-like illness, although 21% of residents in 1 of the 3 wards that had confirmed cases of hMPV infection had lower respiratory tract infections. The fatality rate was 50% (3 of 6 patients) among confirmed cases and 9.4% (9 of 96 patients) among patients with possible cases. A patient with a fatal case had histopathological findings that confirmed the presence of hMPV RNA and proteins in the bronchiolar epithelium of affected lobes. Phylogenetic analysis revealed the presence of 2 distinct strains of hMPV circulating simultaneously on different wards.
Conclusion. hMPV can be associated with important outbreaks of acute respiratory tract infection in elderly institutionalized persons. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Title:An Outbreak of Severe Respiratory Tract Infection Due to Human Metapneumovirus in a Long-Term Care Facility
人类偏肺呼吸道病毒感染在长期使用护理设备病人的爆发
Author: Guy Boivin,1 Gaston De Serres,2 Marie-Eve Hamelin,1 Stéphanie Côté,1 Marco Argouin,3 Geneviève Tremblay,4 Renée Maranda-Aubut,4 Chantal Sauvageau,4 Manale Ouakki,2 Nicole Boulianne,2 and Christian Couture5
Resource:Clinical Infectious Diseases 2007;44:1152-1158来源：临床感染疾病2007；44：1152-1158
Background. Human metapneumovirus (hMPV) is a newly described paramyxovirus that is mainly associated with bronchiolitis in children. We sought to describe the epidemiological, virological, and histopathological findings associated with a large outbreak of hMPV infection in a long-term care facility.
背景：人类偏肺病毒是一种新型副黏液病毒，主要引起儿童细支气管炎。我们试图对长期使用护理设备病人偏肺病毒爆发的流行病学、病毒学组织病理学发现进行描述。
Methods. An investigation of the outbreak was performed by public health authorities, who used standardized questionnaires to collect relevant clinical information from all residents of the facility. Nasopharyngeal samples were obtained from a subset of patients who had influenza-like illnesses for testing by viral culture and reverse-transcriptase polymerase chain reaction. Lung tissue samples from a patient whose case was fatal were available for molecular, histopathological, and immunohistochemical testing.
方法：由公共卫生机构开展疾病爆发的调查研究，采用标准化的问卷收集所有住院病人的相关临床信息，一组具有流感样疾病的患者的鼻烟部样本被收集进行病毒培养和逆转录聚合酶链反应。一名死亡患者的肺组织标本用于分子、组织病理学、免疫组化检测。
Results. A total of 96 (27%) of 364 residents of a long-term care facility presented with respiratory or constitutional symptoms between 1 January 2006 and 15 February 2006.结果。在2006年1月1日至2006年2月15 日期间，一个长期护理机构的364个居住者中总共有96人（27%）出现了呼吸或者全身症状 。The attack rate in the most affected ward was 72% (31 of 43 patients), 感染最重的病区发病率为72%（43人中31人发病）六例经聚合酶链反应证实人类偏肺病毒感染病例中4人发病。相反，5例聚合酶链反应阳性标本仅2例偏肺病毒培养结果阳性。which included 4 of the 6 polymerase chain reaction–confirmed cases of hMPV infection. In contrast, viral culture results were positive for hMPV in only 2 of the 5 polymerase chain reaction–positive samples tested. The most reported diagnosis was an upper respiratory tract infection or an influenza-like illness, although 21% of residents in 1 of the 3 wards that had confirmed cases of hMPV infection had lower respiratory tract infections. The fatality rate was 50% (3 of 6 patients) among confirmed cases and 9.4% (9 of 96 patients) among patients with possible cases. .A patient with a fatal case had histopathological findings that confirmed the presence of hMPV RNA and proteins in the bronchiolar epithelium of affected lobes. Phylogenetic analysis revealed the presence of 2 distinct strains of hMPV circulating simultaneously on different wards.
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作者:admin@医学,生命科学 2010-12-09 05:11
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