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【drug-news】新药能防止前列腺肥大
New drug could prevent prostate gland swelling
Regulating estrogen hormone in men shows promise, scientists say
LONDON - Drugs that regulate the hormone estrogen may help to prevent enlargement of the prostate gland in older men, Australian scientists said on Monday.
Early results from animal studies presented at a medical conference in London showed that an experimental estrogen-regulating drug prevented the swelling of the prostate gland which occurs as men age.
“We still have to try the drugs in humans, but so far these are very promising results,” said Professor Gail Risbridger, of Monash University in Melbourne.
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“This work holds out the possibility that we may be able to help patients with benign disease as well as men with prostate cancer by using these designer drugs.”
The prostate is a small gland about the size of a walnut. An enlarged prostate, or benign prostate hyperplasia (BPH), usually affects men over 60. It can cause urinary problems, infections and be very painful.
Estrogen is considered a female hormone but it also plays a role in the development of the prostate gland. The hormone has both positive and negative effects.
“There are two things that estrogens do, good and bad, but in different diseases,” Risbridger told Reuters.
The bad effect is that the hormone can drive malignancy but on the positive side it can stop BPH from developing.
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Risbridger and her team tested the experimental drug, an estrogen receptor-beta agonist, on transgenic mice with BPH. In a study presented at the Society for Endocrinology conference, she said the drug activated just one of the two cell receptors for the hormone to produce the positive impact.
The scientists found regulating the estrogen receptor beta stopped the development of benign prostate hyperplasia, while the negative effects were due to switching on the estrogen receptor alpha.
“When you give one of the estrogen selective drugs that only activates a particular type of estrogen receptor, beta, you can prevent the hyperplasia from developing,” she said.
In the mice, the drug stopped development of the illness and improved the health of the animals which had existing BPH.
“Ideally, we would want to promote the good effects of estrogen receptor beta and block the bad effects of estrogen receptor alpha,” Risbridger added.
“It’s interesting work, and we are pleased that preclinical testing may translate into real benefits for patients,”
Copyright 2006 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content is expressly prohibited without the prior written consent of Reuters. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 New drug could prevent prostate gland swelling
Regulating estrogen hormone in men shows promise, scientists say
新药有望预防前列腺肥大
科学家称，可通过调节男性雌激素来预防（前列腺肥大）
LONDON - Drugs that regulate the hormone estrogen may help to prevent enlargement of the prostate gland in older men, Australian scientists said on Monday.
伦敦－澳大利亚科学家本周一称，调节雌激素的药物可能有助于防止老年男性前列腺增大。
Early results from animal studies presented at a medical conference in London showed that an experimental estrogen-regulating drug prevented the swelling of the prostate gland which occurs as men age.
在伦敦举办的一个医学会议上发布的早期动物研究结果显示，一种可调节雌激素的试验药可防止老年男性发生前列腺肥大。
“We still have to try the drugs in humans, but so far these are very promising results,” said Professor Gail Risbridger, of Monash University in Melbourne.
“虽然我们必须在人体试验此药，但目前为止结果显示该药还是极有希望的，”墨尔本莫纳什大学的Gail Risbridger教授说道。
“This work holds out the possibility that we may be able to help patients with benign disease as well as men with prostate cancer by using these designer drugs.”
“这就使我们对用这些策划药治疗良性前列腺疾病（BPH）及前列腺癌患者抱有希望。”
The prostate is a small gland about the size of a walnut. An enlarged prostate, or benign prostate hyperplasia (BPH), usually affects men over 60. It can cause urinary problems, infections and be very painful.
前列腺是一个胡桃大小的小腺体。前列腺肥大或BPH，通常影响60岁以上男性。它可引起尿道疾病、尿路感染、尿痛等。
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作者:admin@医学,生命科学 2010-10-04 17:11
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