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【drug-news】亚硝酸钠治疗可提高缺血诱导的血管
据5月27日的PNAS报道，亚硝酸钠在鼠类后肢缺血的动物模型中，可以迅速提高缺血诱导的血管新生并恢复血流。
These findings suggest that sodium nitrite could be a useful treatment for peripheral artery disease and critical limb ischemia. The chemical already has a proven safety record and is also less expensive than other agents currently used treat these conditions.
这一研究发现表明，亚硝酸钠疗法可能成为对付外周动脉疾病或急性肢体缺血的一种有效方案。此药物有一定的安全数据且相比于目前对于治疗缺血性疾病的其他药物，它要便宜得多。
"The most striking finding was how quickly sodium nitrite restored ischemic tissue blood flow and vascular growth," senior investigator Dr. Christopher G. Kevil told Reuters Health. "This is coupled with the fact that very low levels of sodium nitrite (low microgram/Kg doses) were needed to see the beneficial effects."
“最有意义的研究结果是到底亚硝酸钠促进血流恢复和血管新生的速度能有多块，”高级研究员Christopher G. Kevil 博士说。“再加上一个事实：低剂量水平的亚硝酸钠也必须产生有益效应。”
Dr. Kevil, a researcher with Louisiana State University Health Sciences Center in Shreveport, said that in prior studies, his team and others identified agents with pro-angiogenic effects, but that none of them worked as quickly as sodium nitrite. For instance, he said, sildenafil takes 7 days to augment angiogenesis, while sodium nitrite takes just 3.
Dr. Kevil explained that nitrite has typically been viewed as an end product of nitric oxide metabolism with no real significance. However, in tissues with low oxygen tension or pH, the nitrite can convert back to nitric oxide, thereby causing selective angiogenesis and arteriogenesis in ischemic tissues.
In the study, the beneficial effects of nitrite therapy were completely eliminated when the animals were treated with carboxy PTIO, a nitric oxide scavenger.
"Several questions remain to be addressed in future studies such as how exactly does nitrite stimulate endothelial cell proliferation and angiogenesis, and is sodium nitrite therapy effective at stimulating ischemia-induced angiogenesis in other organs (e.g. the heart and brain)," Dr. Kevil said.
He added that his team is now in the planning stages of clinical trials to investigate the effects of sodium nitrite in patients with peripheral vascular disease.
Proc Natl Acad Sci USA 2008;105:7540-7545.
自己译了一半，呵呵 这一研究发现表明，亚硝酸钠疗法可能成为对付外周动脉疾病或急性肢体缺血的一种有效方案。此药物有一定的安全数据且相比于目前对于治疗缺血性疾病的其他药物，它要便宜得多。…… This is coupled with the fact that very low levels of sodium nitrite (low microgram/Kg doses) were needed to see the beneficial effects
不妨译作:即使低剂量水平的亚硝酸钠(毫克/公斤)也有研究其获益的必要
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作者:admin@医学,生命科学 2010-10-02 05:11
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