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【medical-news】HIV病毒可在人睾丸的免疫细胞中分
Human testis harbors HIV-1 in resident immune cells
Rennes, France -- Researchers have demonstrated HIV replication within resident immune cells of the testis, providing an explanation for the persistence of virus in semen even after effective highly active antiretroviral therapy. The related report by Roulet et al., 揝usceptibility of human testis to human immunodeficiency virus-1 infection in situ and in vitro,?appears in the December issue of The American Journal of Pathology.
According to the most recent World Health Organization data, 39.5 million people are infected with HIV. Semen remains the main means of spreading the virus, even though highly active antiretroviral therapy (HAART) can successfully suppress virus in the blood. The presence of HIV in the semen despite successful HAART has intrigued scientists.
Researchers led by Dr. Nathalie Dejucq-Rainsford examined testis tissue for the presence of HIV receptors. They found that all of the necessary cellular receptors (CD4, CXCR4, CCR5, and DC-SIGN) were present on cells located within the testis, specifically testicular macrophages.
The point was demonstrated further by using explanted organ cultures in which human testis tissue was grown in culture. This testis culture, which retained the same tissue architecture as in vivo tissue and continued to secrete testosterone, was able to support infection by HIV-1. Virus produced from the testis culture was fully active as collected virus was able to infect permissive cells in culture.
The finding that HIV-1 can replicate within testicular macrophages is significant because the testis represents a pharmacological sanctuary梞any anti-retroviral drugs have difficulty penetrating this organ and may be present at sub-therapeutic levels. Thus, although HAART may achieve undetectable virus levels in the blood, virus replication in the testis may permit continued spread of the virus.
Finally, with HIV infection continuing to rise, the development of anti-retroviral therapy that effectively targets all sources of HIV, including the testis, is gravely needed. The use of this testis culture system may allow assessment of new anti-retroviral drugs that target HIV in the testis. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 真若如此，可就有点麻烦了...期待楼上战友的翻译快快出炉... 对不起,前几天领的东西确实没翻译,抱歉,一定尽快补上. Rennes, France -- Researchers have demonstrated HIV replication within resident immune cells of the testis, providing an explanation for the persistence of virus in semen even after effective highly active antiretroviral therapy. The related report by Roulet et al., 揝usceptibility of human testis to human immunodeficiency virus-1 infection in situ and in vitro,?appears in the December issue of The American Journal of Pathology.
法国雷恩（地名）报道――研究人员已经证实HIV病毒在睾丸的免疫细胞中复制增殖，这恰恰说明了为什么病人在通过高效抗逆转录酶疗法之后精液中仍然有病毒存在。在十二月份出版的美国临床病理学期刊上，Roulet等人报道了“人类睾丸对免疫缺陷病毒－1的易感染性”相关问题。
According to the most recent World Health Organization data, 39.5 million people are infected with HIV. Semen remains the main means of spreading the virus, even though highly active antiretroviral therapy (HAART) can successfully suppress virus in the blood. The presence of HIV in the semen despite successful HAART has intrigued scientists.
世界卫生组织数据显示，已经有3950万人感染HIV病毒，即使高效抗逆转录酶疗法能抑制血液中的病毒活性，但还是控制不了精液传播的病毒，这已经大大激起了科学家的兴趣。
Researchers led by Dr. Nathalie Dejucq-Rainsford examined testis tissue for the presence of HIV receptors. They found that all of the necessary cellular receptors (CD4, CXCR4, CCR5, and DC-SIGN) were present on cells located within the testis, specifically testicular macrophages.
以Nathalie Dejucq-Rainsford为首的研究人员分析了睾丸中的HIV受体，他们发现在睾丸细胞表面，特别是睾丸巨噬细胞表面，存在CD4, CXCR4, CCR5, 和 DC-SIGN这些人类必需的受体。 剩下的晚上之前交上 The point was demonstrated further by using explanted organ cultures in which human testis tissue was grown in culture. This testis culture, which retained the same tissue architecture as in vivo tissue and continued to secrete testosterone, was able to support infection by HIV-1. Virus produced from the testis culture was fully active as collected virus was able to infect permissive cells in culture.
通过对人睾丸组织培养进一步证实了这点，这些培养的细胞和活体中一样分泌睾丸激素，能被HIV－1病毒感染，培养物中的病毒和体内收集的病毒都能感染容许性细胞。
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作者:admin@医学,生命科学 2010-09-27 12:36
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