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【Nat Rev Cancer】实体瘤中乏氧，HIF1与葡萄糖代谢
It has been known for many years that cellular metabolism within the solid tumour is markedly different from that of the corresponding normal tissue. The transcription factor hypoxia-inducible factor 1 (HIF1) has been implicated in regulating many of the genes that are responsible for the metabolic difference. However, it remains unclear how this 'aerobic glycolysis', originally described by Otto Warburg, offers tumour cells a growth advantage. As discussed in this Perspective, new data suggests that this metabolic switch may provide a benefit to the tumour not by increasing glycolysis but by decreasing mitochondrial activity.
http://www.nature.com/nrc/journal/v8/n9/abs/nrc2468.html 本人已认领此文，若48小时未提交，请其它战友领取。 本人已认领此文，若48小时未提交，请其它战友领取。 Hypoxia, HIF1 and glucose metabolism in the solid tumour
实体瘤中低氧,HIF-1和糖代谢
It has been known for many years that cellular metabolism within the solid tumour is markedly different from that of the corresponding normal tissue.
众所周知,实体瘤中的细胞代谢与其正常组织有所不同.
The transcription factor hypoxia-inducible factor 1 (HIF1) has been implicated in regulating many of the genes that are responsible for the metabolic difference.
转录因子低氧诱导因子1(HIF1)已被证明可以调节多个参与代谢活动的基因.
However, it remains unclear how this 'aerobic glycolysis', originally described by Otto Warburg, offers tumour cells a growth advantage.
但是,由Otto Warburg提出的有氧糖酵解如何给肿瘤带来生长优势的相关问题至今仍是个迷.
As discussed in this Perspective, new data suggests that this metabolic switch may provide a benefit to the tumour not by increasing glycolysis but by decreasing mitochondrial activity.
目前,该方面研究中认为肿瘤细胞是通过降低线粒体功能而非增加糖酵解获得生长优势.
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作者:admin@医学,生命科学 2010-09-22 02:34
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