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【medical-news】多吃含镁食品预防胆结石
February 22, 2008 — Consumption of a diet rich in magnesium appears to reduce the risk of symptomatic gallstone disease, according to findings from a US study of over 42,000 men.
Dietary consumption of magnesium has been declining over the years, lead author Dr. Chung-Jyi Tsai and colleagues note, due in part to the overprocessing of foods.
Magnesium deficiency is known to cause elevated triglyceride levels and decreased HDL cholesterol levels, both of which may raise the risk of gallstones. Still, the long-term effect of magnesium consumption level on the risk of gallstones in humans was not known.
To investigate, Dr. Tsai, from the University of Kentucky Medical Center in Lexington, and colleagues analyzed data from 42,705 men, between 40 and 75 years of age, who were enrolled in the Health Professionals Follow-up Study. The men were followed from 1986 to 2002.
The subjects were surveyed every 2 years to assess the occurrence of new illnesses, including gallbladder disease. Magnesium consumption was determined with a semiquantitative food frequency questionnaire sent to the subjects every 4 years.
During 560,810 person-years of follow-up, 2195 men were diagnosed with symptomatic gallstone disease, the report shows.
Compared with the lowest quintile of total magnesium intake (median 262 mg/day), the highest quintile of intake (454 mg/day) reduced the risk of gallstone disease by 33%. The same risk reduction was seen when considering just dietary magnesium (excludes supplements).
After adjusting for potential confounding factors, the corresponding risk reductions fell slightly to 28% and 32%.
"From many studies by this group and others, it appears that a generally healthy dietary pattern, with more plant-based foods, fiber, and increasing complex carbohydrates, and now increasing magnesium intake will decrease the risk of symptomatic gallstones and cholecystectomy," Dr. Cynthia W. Ko, from the University of Washington in Seattle, writes in an accompanying editorial. "This 'healthy' dietary pattern will also help in prevention of other chronic diseases in addition to gallstones."
Am J Gastroenterol. 2008;103:375-382.
http://www.medscape.com/viewarticle/570527 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Magnesium Intake May Cut Risk of Gallstones
补充镁降低患胆结石风险
February 22, 2008 — Consumption of a diet rich in magnesium appears to reduce the risk of symptomatic gallstone disease, according to findings from a US study of over 42,000 men.
2008年2月22日----根据美国一项超过4200名男性参加的研究结果提示，进食含镁丰富的食物能降低患症状性胆结石的风险。
Dietary consumption of magnesium has been declining over the years, lead author Dr. Chung-Jyi Tsai and colleagues note, due in part to the overprocessing of foods.
第一作者Chung-Jyi Tsai博士和他的同事认为，由于食物的过度处理，在过去这些年里，人们进食的食物的含镁量在下降。
Magnesium deficiency is known to cause elevated triglyceride levels and decreased HDL cholesterol levels, both of which may raise the risk of gallstones. Still, the long-term effect of magnesium consumption level on the risk of gallstones in humans was not known.
镁缺乏可以引起甘油三酯的升高和HDL胆固醇水平的下降。而这种情况（甘油三酯的升高和HDL胆固醇水平的下降）又会增加胆结石的患病风险。而且，镁摄入水平的远期作用与人患胆结石症风险之间的关系，我们知道的甚少。
To investigate, Dr. Tsai, from the University of Kentucky Medical Center in Lexington, and colleagues analyzed data from 42,705 men, between 40 and 75 years of age, who were enrolled in the Health Professionals Follow-up Study. The men were followed from 1986 to 2002.
为了研究这一问题，来自列克星敦肯塔基大学医学中心的Tsai博士和其同事分析了42705名年龄在40到75岁男性的资料，这些男性参加了医疗专业人员的随访研究。
The subjects were surveyed every 2 years to assess the occurrence of new illnesses, including gallbladder disease. Magnesium consumption was determined with a semiquantitative food frequency questionnaire sent to the subjects every 4 years.
参加者没隔一年进行新疾病的筛查，这些疾病包括胆囊疾病。镁的摄入情况是通过每4年向参加者发放半定量的食物频率问卷表来调查的。
During 560,810 person-years of follow-up, 2195 men were diagnosed with symptomatic gallstone disease, the report shows.
研究提示，在560810人年的随访期内，2195例男性被诊断为症状性胆石症。
Compared with the lowest quintile of total magnesium intake (median 262 mg/day), the highest quintile of intake (454 mg/day) reduced the risk of gallstone disease by 33%. The same risk reduction was seen when considering just dietary magnesium (excludes supplements).
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作者:admin@医学,生命科学 2011-05-05 17:01
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