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【bio-news】抗氧化剂缺乏可导致肺高压
A recent study shows that a loss of antioxidants in the endothelial cells that line blood vessels in the lungs contributes to the loss of vasodilator effects and, ultimately, to the development of pulmonary hypertension.
The study, led by Serpil Erzurum of the Cleveland Clinic, evaluated antioxidant activities in patients with idiopathic pulmonary arterial hypertension (IPAH), a fatal disease characterized by progressive increase in pulmonary artery pressure and vascular resistance.
Erzurum's study found that the inactivation of these oxidants inside the cell is achieved mainly by the cell's own line of defense against oxidants. Additionally, the researchers determined that this process may contribute to low levels of nitric oxide, identified in IPAH and a fundamental component in the pathogenesis of pulmonary hypertension.
According to Dr. Erzurum, there is a potential long-term benefit to the care of patients with IPAH due to the study's findings. "Antioxidant augmentation in patients might be used to increase nitric oxide vasodilator effects, reduce pulmonary artery pressures and potentially improve clinical outcomes," she said.
http://www.sciencedaily.com/releases/2008/09/080923164718.htm 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Antioxidant Deficiency Linked To Pulmonary Hypertension
抗氧化剂缺乏可导致肺高压
A recent study shows that a loss of antioxidants in the endothelial cells that line blood vessels in the lungs contributes to the loss of vasodilator effects and, ultimately, to the development of pulmonary hypertension.
一项近期的研究表明，肺血管内皮细胞缺乏抗氧化剂会导致血管舒张功能受损，并最终发展成肺（动脉）高压。
The study, led by Serpil Erzurum of the Cleveland Clinic, evaluated antioxidant activities in patients with idiopathic pulmonary arterial hypertension (IPAH), a fatal disease characterized by progressive increase in pulmonary artery pressure and vascular resistance.
由克利夫兰临床中心的Serpil Erzurum主持的这项研究评估了患有原发性肺动脉高压的病人体内抗氧化剂的活性，原发性肺动脉高压是一种以肺动脉压力和血管阻力进行性增加为特征的致命性疾病。
Erzurum's study found that the inactivation of these oxidants inside the cell is achieved mainly by the cell's own line of defense against oxidants. Additionally, the researchers determined that this process may contribute to low levels of nitric oxide, identified in IPAH and a fundamental component in the pathogenesis of pulmonary hypertension.
Erzurum的研究发现血管上皮细胞自身对氧化剂的防御作用是这些氧化剂失活的主要原因。另外，研究者认为这个过程是由于低水平的一氧化氮引起的。一氧化氮被确定存在于原发性肺动脉高压中，并且是肺动脉高压发病机理中的一个基础成分。
According to Dr. Erzurum, there is a potential long-term benefit to the care of patients with IPAH due to the study's findings. "Antioxidant augmentation in patients might be used to increase nitric oxide vasodilator effects, reduce pulmonary artery pressures and potentially improve clinical outcomes," she said.
Erzurum博士谈到，该研究的发现，对于患有原发性肺动脉高压的病人的护理，具有潜在的长期益处。她说：“病人中抗氧化剂的强化使用可能增强一氧化氮的血管舒张作用，降低肺动脉压力并对促进临床康复具有潜在作用。”
编译：
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题目：抗氧化剂缺乏可导致肺高压
一项近期的研究表明，肺血管内皮细胞缺乏抗氧化剂会导致血管舒张功能受损，并最终发展成肺（动脉）高压。
由克利夫兰临床中心的Serpil Erzurum主持的这项研究评估了患有原发性肺动脉高压的病人体内抗氧化剂的活性。原发性肺动脉高压是一种以肺动脉压力和血管阻力进行性增加为特征的致命性疾病。
Erzurum的研究发现血管上皮细胞自身对氧化剂的防御作用是这些氧化剂失活的主要原因。另外，研究者认为这个过程是由于低水平的一氧化氮引起的。一氧化氮被确定存在于原发性肺动脉高压中，并且是肺动脉高压发病机理中的一个基础成分。
Erzurum博士谈到，该研究的发现，对于患有原发性肺动脉高压的病人的护理，具有潜在的长期益处。她说：“病人中抗氧化剂的强化使用可能增强一氧化氮的血管舒张作用，降低肺动脉压力并对促进临床康复具有潜在作用。” [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-04-30 17:11
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