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【bio-news】科学家寻找ALS基因病因
03/21/07 -- U.S. scientists have conducted the first genome-wide search for the genetic cause of amyotrophic lateral sclerosis, also known as Lou Gehrig's disease.
The Johns Hopkins University researchers say they identified 34 new unique variations in the human genetic code among 276 unrelated subjects with ALS.
The medical investigators said the 34 so-called single nucleotide polymorphisms represent good candidate genes predisposing people to the non-inherited form of the fatal neurodegenerative disease.
"Although we haven't located the exact gene responsible for sporadic ALS, our results seriously narrow the search and bring us that much closer to finding what we need to start developing treatments for the disease," said Dr. Bryan Traynor.
ALS kills 10,000 Americans each year, with an estimated one in 2,000 people at risk of developing the disease.
Genes behind inherited forms of ALS -- responsible for about 5 percent of all cases -- were discovered a decade ago but no genetic roots have previously been found for sporadic ALS, which occurs in people without a family history of the disease.
The Johns Hopkins research is described in the online version of the journal Lancet Neurology.
Source: Johns Hopkins University
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=27300012 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Scientists Hunt Genetic Cause of ALS
科学家寻找ALS基因病因
03/21/07 -- U.S. scientists have conducted the first genome-wide search for the genetic cause of amyotrophic lateral sclerosis, also known as Lou Gehrig's disease.
The Johns Hopkins University researchers say they identified 34 new unique variations in the human genetic code among 276 unrelated subjects with ALS.
据3月21日新闻报道，美国科学家们发起了第一次基因组普查来寻找肌萎缩性脊髓侧索硬化症（ALS）俗称葛雷克氏症的遗传学病因。约翰.霍普金斯大学的研究人员声称他们在276个与ALS无关的人类遗传密码子中找到了34个新的独特的基因突变。医学观察员说这34个所谓单核苷酸多态性表明某些候选基因可以使人们不遗传致死性神经退行性病变。
The medical investigators said the 34 so-called single nucleotide polymorphisms represent good candidate genes
predisposing people to the non-inherited form of the fatal neurodegenerative disease.
"Although we haven't located the exact gene responsible for sporadic ALS, our results seriously narrow the search and bring us that much closer to finding what we need to start developing treatments for the disease," said Dr. Bryan Traynor.
Bryan Traynor博士说：“尽管我们还没有精确定位到是哪些基因导致散发性的ALS，但我们的研究结果明显减小了基
因的查找范围，使我们更好的明白从哪里着手发展ASL的治疗策略。
ALS kills 10,000 Americans each year, with an estimated one in 2,000 people at risk of developing the disease.
ASL在美国每年导致一万人死亡，估计2000人中就有1人有患ASL的风险。
Genes behind inherited forms of ALS -- responsible for about 5 percent of all cases -- were discovered a decade ago but no genetic roots have previously been found for sporadic ALS, which occurs in people without a family history of the disease.
遗传型ASL的遗传背景——10年前发现遗传型的ASL占所有ASL病例的5％，但以前并没有发现散发性ASL（家族中并没有ASL病史）的遗传学病因。
The Johns Hopkins research is described in the online version of the journal Lancet Neurology.
约翰.霍普金斯大学的研究结果发表在《柳叶刀》杂志的网络版上。
Source: Johns Hopkins University
来源：约翰.霍普金斯大学 编译：
科学家寻找ALS基因病因
据3月21日新闻报道，美国科学家们发起了第一次基因组普查来寻找肌萎缩性脊髓侧索硬化症（ALS）俗称葛雷克氏症的遗传学病因。约翰.霍普金斯大学的研究人员声称他们在276个与ALS无关的人类遗传密码子中找到了34个新的独特的基因突变。医学观察员说这34个所谓单核苷酸多态性表明某些候选基因可以使人们不遗传致死性神经退行性病变。Bryan Traynor博士说：“尽管我们还没有精确定位到是哪些基因导致散发性的ALS，但我们的研究结果明显减小了基因的查找范围，使我们更好的明白从哪里着手发展ASL的治疗策略。
ASL在美国每年导致一万人死亡，估计2000人中就有1人有患ASL的风险。遗传型ASL的遗传背景——10年前发现遗传型的ASL占所有ASL病例的5％，但以前并没有发现散发性ASL（家族中并没有ASL病史）的遗传学病因。
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作者:admin@医学,生命科学 2011-01-19 05:14
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