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【medical-news】硝酸盐在骨矿物质密度中的使用和
Jamal SA, Goltzman D, Hanley DA, Papaioannou A, Prior JC, Josse RG.
Osteoporos Int. 2008 Sep 18.
http://www.ncbi.nlm.nih.gov/sites/entrez
Summary Nitrates may have beneficial effects on bone. To determine if nitrates were associated with increased bone mineral density (BMD), we conducted a secondary analysis using data from subjects in a prospective study. Subjects reporting nitrate use had increased BMD compared with non-users, confirming that nitrates have positive BMD effects in women and men.
Introduction Prior studies suggest positive associations between nitrates and bone.
Methods We used linear regression models, stratified by gender and adjusted for age, weight, and baseline differences, to determine the association between daily nitrate use and BMD among subjects participating in the Canadian Multicentre Osteoporosis Study. All results are reported as annualised percent change in BMD at the hip and spine among nitrate users compared to non-users.
Results We included 1,419 men (71 reported daily nitrate use) and 2,587 women (97 reported daily nitrate use). Male non-users had decreased hip BMD (−1.3%; 95% confidence interval [95%CI] = −1.6 to −1.1) and increased spine BMD (2.8%; 95%CI = 2.5 to 3.1). Male nitrate users had increased hip BMD (1.4%; 95%CI = 0.1 to 2.8) and spine BMD (4.5%; 95%CI = 3.2 to 5.7). Among women, non-users had decreased hip BMD (−1.9; 95%CI = −2.1 to −1.7) and increased spine BMD (2.1%; 95%CI = 1.9 to 2.4) whilst users had an increase in hip BMD (2.0%; 95%CI = 1.2 to 2.8) and spine BMD (4.1%; 95%CI = 3.4 to 4.9).
Conclusion Nitrate use is associated with increased BMD at the hip and spine in men and women. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。
Nitrate use and changes in bone mineral density: the Canadian Multicentre Osteoporosis Study
硝酸盐使用和骨密度变化：加拿大骨质疏松多中心研究
Jamal SA, Goltzman D, Hanley DA, Papaioannou A, Prior JC, Josse RG.
Osteoporos Int. 2008 Sep 18.
http://www.ncbi.nlm.nih.gov/sites/entrez
Summary Nitrates may have beneficial effects on bone. To determine if nitrates were associated with increased bone mineral density (BMD), we conducted a secondary analysis using data from subjects in a prospective study. Subjects reporting nitrate use had increased BMD compared with non-users, confirming that nitrates have positive BMD effects in women and men.
总体上硝酸盐对骨骼是有益处的。为证实硝酸盐与骨密度增加是否相关联，我们进行了一项前瞻性研究，并对研究数据行二次分析。结果表明与不使用硝酸盐者比较，在硝酸盐使用者中可以观察到骨密度增加，证实硝酸盐对提高人类骨密度有正性作用。
Introduction Prior studies suggest positive associations between nitrates and bone.
Methods We used linear regression models, stratified by gender and adjusted for age, weight, and baseline differences, to determine the association between daily nitrate use and BMD among subjects participating in the Canadian Multicentre Osteoporosis Study. All results are reported as annualised percent change in BMD at the hip and spine among nitrate users compared to non-users.
摘要 研究表明硝酸盐与骨骼有正性相关作用
方法 在加拿大骨质疏松多中心研究中，我们采用线性回归模式，按实验者性别分组并调整年龄，体重和基线差异，证实每日使用硝酸盐与骨密度的关联性。结果通过硝酸盐使用者与非使用者髂骨和脊柱的年骨密度改变百分比来表示
Results We included 1,419 men (71 reported daily nitrate use) and 2,587 women (97 reported daily nitrate use). Male non-users had decreased hip BMD (−1.3%; 95% confidence interval [95%CI] = −1.6 to −1.1) and increased spine BMD (2.8%; 95%CI = 2.5 to 3.1). Male nitrate users had increased hip BMD (1.4%; 95%CI = 0.1 to 2.8) and spine BMD (4.5%; 95%CI = 3.2 to 5.7). Among women, non-users had decreased hip BMD (−1.9; 95%CI = −2.1 to −1.7) and increased spine BMD (2.1%; 95%CI = 1.9 to 2.4) whilst users had an increase in hip BMD (2.0%; 95%CI = 1.2 to 2.8) and spine BMD (4.1%; 95%CI = 3.4 to 4.9).
结果 实验包括1419位男性（其中71位每日使用硝酸盐）和2587位女性（其中97位每日使用硝酸盐）。在男性实验者中，不使用硝酸盐者可以观察到髋骨骨密度下降(−1.3%; 95% 可信区间[95%CI] = −1.6 to −1.1)但脊柱骨密度增加 (2.8%; 95%可信区间 = 2.5 to 3.1)，使用硝酸盐者则可以观察到髋骨(1.4%; 95%CI = 0.1 to 2.8) 和脊柱骨密度(4.5%; 95%CI = 3.2 to 5.7）均有增加。在女性实验者中，不使用硝酸盐者观察到髋骨骨密度下降(−1.9; 95%CI = −2.1 to −1.7) 和脊柱骨密度增加(2.1%; 95%CI = 1.9 to 2.4) ，使用硝酸盐者两者均增加(髋骨2.0%; 95%CI = 1.2 to 2.84. 脊柱 1%; 95%CI = 3.4 to 4.9).
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作者:admin@医学,生命科学 2010-09-26 18:32
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