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【medical-news】胰腺癌术后的放化疗可以大大延长
1/22/2007
By: Reuters Health
NEW YORK (Reuters Health), Jan 22 - Combined radiation and chemotherapy following the complete removal of invasive pancreatic cancer can prolong survival for several months or even years for some patients, according to the results of a new study.
The findings, reported Saturday at the 2007 Gastrointestinal Cancers Symposium in Orlando, Florida, are good news since the outlook after a diagnosis of pancreatic cancer is generally poor. "It is a very aggressive cancer that metastasizes (spreads) early," presenter Dr. Michele M. Corsini, from the Mayo Clinic in Rochester, Minnesota, told Reuters Health.
Corsini and her colleagues looked at the records of patients at their institution who had undergone complete surgical removal of pancreatic cancer in hopes of a cure. After the operation, "we offer the combination of chemotherapy and radiation therapy," usually within six weeks, Corsini explained.
"Between 1975 and 2005, there were 472 patients who had good surgery (results), with ... no evidence of cancer at all," she reported. "For nine of them, by the time they returned for follow-up -- within weeks -- they already had metastatic disease." Three others were lost to follow-up, and nine had add-on chemo only.
The final analysis included 180 patients who received no additional therapy; 246 who had radiation and chemotherapy; and 28 who received radiation and chemotherapy followed by another course of chemotherapy.
The average overall survival was 1.6 years among those who received no extra therapy; 2.1 years among those who received radiation and chemotherapy; and 2.9 years among those treated with radiation and chemotherapy plus a second round of chemotherapy. After five years, the overall survival in the three groups was 17%, 28% and 34%, respectively.
Patients who had disease in the lymph nodes and high-grade tumors especially benefited from chemoradiation, Corsini said.
Those who did not undergo extra treatment had the least serious condition. "They were the best performers, which is probably why they were not offered radiation and chemotherapy. But ultimately, unfortunately, they did the worst," Corsini concluded.
By Karla Gale
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1/22/2007
By: Reuters Health
胰腺癌术后的放化疗可以大大延长病人的生存时间
2007年1月22日
消息来源：路透社健康频道
NEW YORK (Reuters Health), Jan 22 - Combined radiation and chemotherapy following the complete removal of invasive pancreatic cancer can prolong survival for several months or even years for some patients, according to the results of a new study.
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