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【medical-news】骨质疏松与基因

http://www.eurekalert.org/pub_releases/2006-10/ra-brs101906.php

Bone research strengthened in lead up to World Osteoporosis Day
As many as 100,000 Australians could be carrying a genetic mutation that predisposes them to low bone density and a higher risk of bone fractures.

Bone researchers at Griffith University are now in a position to further advance knowledge of such mutations following the announcement this week of a substantial funding win from the National Health and Medical Research Council.

World Osteoporosis Day is tomorrow (Friday, October 20).

Chief investigator Dr Nigel Morrison from Griffith's Genomics Research Centre said the RUNX2 gene was a master regulator that controlled the development of bone cells or osteoblasts.

Animal studies have confirmed that the gene is critical to bone development, and there are known mutations in humans that can cause extremely rare but severe bone disease.

"However, what we are particularly interested in, is understanding the variants of the gene that impact on more common diseases such as osteoporosis," Dr Morrison said.

"This gene is also expressed in cartilage and it may be that gene variants also have effects on conditions such as osteoarthritis."

Both diseases are complex disorders influenced by a combination of genetic and environmental factors. They are also costly diseases that contribute significantly to the burden of disease and disability in Australia.

Dr Morrison said the project would bring together an Australia-wide collaboration of clinical researchers and a US colleague who is a world leader in the functional analysis of bone genes.

"We want to understand the molecular mechanisms that control cell fate in bone ?why stem cells, for example, differentiate into bone cells. To do that we will access information and DNA from extensive clinical databases."

Dr Morrison said most carriers of the RUNX2 gene variants were otherwise healthy people whose bone mineral density would be in the lower part of the normal range. 先领回家再说, 明天来译. Bone research strengthened in lead up to World Osteoporosis Day
As many as 100,000 Australians could be carrying a genetic mutation that predisposes them to low bone density and a higher risk of bone fractures.
多达100000澳大利亚人携带某种突变基因,使他们更容易发生骨密度降低、骨折风险增高。

Bone researchers at Griffith University are now in a position to further advance knowledge of such mutations following the announcement this week of a substantial funding win from the National Health and Medical Research Council.
本周宣布获得全国卫生和医学研究理事会资金后,格里菲斯的研究人员现在的任务是更进一步研究这些突变基因。

World Osteoporosis Day is tomorrow (Friday, October 20).
10月20日是世界骨质疏松症日。

Chief investigator Dr Nigel Morrison from Griffith's Genomics Research Centre said the RUNX2 gene was a master regulator that controlled the development of bone cells or osteoblasts.
格里菲斯染色体研究中心首席研究员Nigel Morrison博士称,RUNX2基因是控制骨细胞及成骨细胞发育的主要调节因素。

Animal studies have confirmed that the gene is critical to bone development, and there are known mutations in humans that can cause extremely rare but severe bone disease.
动物实验已经证实这一基因对骨的发育极其重要,也已知道人类这一基因的某些突变会引起罕见但严重的骨疾病。

"However, what we are particularly interested in, is understanding the variants of the gene that impact on more common diseases such as osteoporosis," Dr Morrison said.
“但是,我们更感兴趣的是,哪些变化可以引起骨质疏松等常见疾病。”

"This gene is also expressed in cartilage and it may be that gene variants also have effects on conditions such as osteoarthritis."
这一基因在软骨也有表达,它的变异很可能与骨关节炎有关。

Both diseases are complex disorders influenced by a combination of genetic and environmental factors. They are also costly diseases that contribute significantly to the burden of disease and disability in Australia.
骨质疏松与骨关节炎受遗传及环境因素综合影响,是两种代价昂贵的复杂疾病,它们导致澳大利亚疾病负担加重,残疾人增加。

Dr Morrison said the project would bring together an Australia-wide collaboration of clinical researchers and a US colleague who is a world leader in the functional analysis of bone genes.
Morrison
Morrison博士称,这一课题将集中澳洲临床研究人员,一位美国同行也将参与合作,他是骨基因功能分析的世界级顶尖人物。

"We want to understand the molecular mechanisms that control cell fate in bone ?why stem cells, for example, differentiate into bone cells. To do that we will access information and DNA from extensive clinical databases."

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作者:admin@医学,生命科学    2011-08-24 05:14
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