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【drug-news】鱼油的功过是非
By BJS
Created 01/14/2008 - 14:59
Fish oil supplements may help some cardiac patients while harming others, suggests a new review of evidence compiled by St. Michael’s Hospital and University of Toronto researchers.
In a systematic review of trials where patients with implantable cardioverter defibrillators used fish oil supplements, Dr. David Jenkins and Dr. Paul Dorian found significant differences among the trials, indicating fish oil may be beneficial to some patients while having a negative impact on others.
“Fish oils can have complex and varied effects on the heart,” says Jenkins, a U of T Professor of Medicine who runs the Clinical Nutrition and Risk Factor Modification Centre at St. Michael’s Hospital. “These effects include blocking cardiac ion channels, reducing fibrosis in response to mechanical stress, decreasing blood coagulation, and possibly altering immune function.”
There is evidence from multiple large-scale population (epidemiologic) studies and randomized controlled trials that intake of recommended amounts of DHA and EPA in the form of dietary fish or fish oil supplements can reduce the risk of death, heart attack and dangerous abnormal heart rhythms in people with known cardiovascular disease, as well as potentially slow hardening of the arteries and lower blood pressure slightly. But the evidence also shows high doses can have harmful effects, such as an increased risk of bleeding. Although benefits are proposed for alpha-linolenic acid, scientific evidence is less compelling and beneficial effects may be less pronounced.
The meta-analysis reveals that studies in different patient populations with different pathophysiologies and therapeutic regimens have all produced divergent results. However, more recent data suggests that particular caution should be exercised when analyzing data from certain subgroups, such as men with stable angina. The same may also be true for patients with implantable cardioverter defibrillators who have a history of ventricular tachycardia and who are not taking antiarrhythmic medications.
“Fish oils have promise as beneficial in cardiovascular disease but our work highlights our gaps in understanding and the need for more research,” adds Dorian, a cardiologist at St. Michael’s Hospital and U of T Professor of Medicine University of Toronto.
The review, which will appear in the January 15 edition of the Canadian Medical Association Journal, also indicates that further research and large randomized controlled trials are needed before long-chain omega-3 fatty acids are used in patients with heart failure and angina.
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Fish oil -- helpful or harmful?
By BJS
Created 01/14/2008 - 14:59
鱼油的功过是非
2008.1.14
Fish oil supplements may help some cardiac patients while harming others, suggests a new review of evidence compiled by St. Michael’s Hospital and University of Toronto researchers.
圣米迦勒医院及多伦多大学的研究人员新整理的一篇综述称，鱼油补充剂对某些心脏病患者有利，而对某些患者有害。
In a systematic review of trials where patients with implantable cardioverter defibrillators used fish oil supplements, Dr. David Jenkins and Dr. Paul Dorian found significant differences among the trials, indicating fish oil may be beneficial to some patients while having a negative impact on others.
在对植入心律转复除颤器的患者服用鱼油补充剂试验所进行的系统综述中，David Jenkins博士及Paul Dorian博士发现了试验的明显差别，这说明鱼油可能对某些患者有益而对某些患者有负面影响。
“Fish oils can have complex and varied effects on the heart,” says Jenkins, a U of T Professor of Medicine who runs the Clinical Nutrition and Risk Factor Modification Centre at St. Michael’s Hospital. “These effects include blocking cardiac ion channels, reducing fibrosis in response to mechanical stress, decreasing blood coagulation, and possibly altering immune function.”
多伦多大学医学教授，圣米迦勒医院临床营养和风险因子修正中心的Jenkins称，“鱼油可能对心脏各种复杂的作用”。“这些作用包括阻塞心脏的离子通道、减少由于机械压力而出现的纤维变性、减少凝血以及可能改变免疫功能。”
There is evidence from multiple large-scale population (epidemiologic) studies and randomized controlled trials that intake of recommended amounts of DHA and EPA in the form of dietary fish or fish oil supplements can reduce the risk of death, heart attack and dangerous abnormal heart rhythms in people with known cardiovascular disease, as well as potentially slow hardening of the arteries and lower blood pressure slightly. But the evidence also shows high doses can have harmful effects, such as an increased risk of bleeding. Although benefits are proposed for alpha-linolenic acid, scientific evidence is less compelling and beneficial effects may be less pronounced.
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作者:admin@医学,生命科学 2011-08-14 17:15
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