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【bio-news】HIV感染的人易骨折
HIV-infected patients have a higher prevalence of fractures than non HIV-infected patients, across both genders and critical fracture sites according to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).
"Prior studies have indicated reduced bone density in HIV-infected patients, but little was known whether fracture risk increased in this population," said Dr. Steven Grinspoon, M.D., of Massachusetts General Hospital in Boston and lead author of the study. "These data are the first to suggest that there is a clinically significant increase in bone fractures among HIV-infected patients, using data from a large healthcare system."
In this study, researchers analyzed data from the Partners HealthCare System, which includes two primary hospitals, Brigham and Women's Hospital and Massachusetts General Hospital. They studied fracture diagnoses from 1996 to 2008 in 8,525 HIV-infected patients and more than 2 million non HIV-infected patients. Dr. Grinspoon and his colleagues found that overall fracture prevalence increased more than 60 percent in HIV-infected patients versus non HIV-infected patients.
The data in this study showed HIV-infected patients had a significantly higher prevalence of vertebral, hip, wrist, and combined fractures compare to non HIV-infected patients. Within both sexes, fracture prevalence was higher in HIV-infected patients for the majority of sites assessed, across age categories.
Dr. Grinspoon said the study found the relative difference in fracture prevalence between HIV-infected patients and non HIV-infected patients increases with age for both sexes. Therefore, as the HIV-infected population ages, reduced bone mineral density and increased fracture risk may become an even greater problem.
"HIV patients with risk for low bone density should be assessed and potentially treated to prevent fractures," said Dr. Grinspoon. "Further research is needed into the mechanisms of bone loss in this population."
http://www.medicalnewstoday.com/articles/119647.php 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 HIV Patients At Greater Risk For Bone Fractures
HIV感染的人易骨折
HIV-infected patients have a higher prevalence of fractures than non HIV-infected patients, across both genders and critical fracture sites according to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).
据一项新的研究，HIV感染者与未感染者相比，有较高的骨折发生率，包括在男女骨折的重要部位。美国内分泌学会主办的《临床内分泌学与代谢杂志》已同意发表这篇论文。
"Prior studies have indicated reduced bone density in HIV-infected patients, but little was known whether fracture risk increased in this population," said Dr. Steven Grinspoon, M.D., of Massachusetts General Hospital in Boston and lead author of the study. "These data are the first to suggest that there is a clinically significant increase in bone fractures among HIV-infected patients, using data from a large healthcare system."
“前期研究表明HIV感染者骨密度减少，但这类群体是否易骨折还知之甚少”。马萨诸塞州综合医院医学博士Steven Grinspoon 医生是这篇论文的第一作者，他说“这些来自大型医疗机构数据首次表明临床上HIV感染者易骨折”。
In this study, researchers analyzed data from the Partners HealthCare System, which includes two primary hospitals, Brigham and Women's Hospital and Massachusetts General Hospital. They studied fracture diagnoses from 1996 to 2008 in 8,525 HIV-infected patients and more than 2 million non HIV-infected patients. Dr. Grinspoon and his colleagues found that overall fracture prevalence increased more than 60 percent in HIV-infected patients versus non HIV-infected patients.
这项研究中，研究人员分析了来自医疗系统合作单位的资料，包括两家主要医院－布赖海姆女子医院和马塞诸塞州综合医院。他们研究了自1996年至2008年间骨折诊断病例，共纳入8525例HIV感染者和2百万未感染者。Grinspoon医生和他的同事发现与未感染者比较，HIV感染者骨折总发生率增加60%。
The data in this study showed HIV-infected patients had a significantly higher prevalence of vertebral, hip, wrist, and combined fractures compare to non HIV-infected patients. Within both sexes, fracture prevalence was higher in HIV-infected patients for the majority of sites assessed, across age categories. [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-08-28 08:06
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