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【bio-news】新的多巴胺脑内作用靶点
Public release date: 23-Jan-2007
New dopamine brain target discovered
Potential breakthrough for schizophrenia treatment
Toronto, ON, January 23, 2007 ?A team of Canadian researchers, lead by Dr. Susan George and Dr. Brian O'Dowd at the Centre for Addiction and Mental health (CAMH), discovered a distinct dopamine signalling complex in the brain. Composed of two different types of dopamine receptors, this novel target may have a significant role in understanding and treating schizophrenia.
Published in the Proceedings of the National Academy of Sciences USA (Rashid et al., 2007), this important discovery demonstrates the existence of a Gq/11-coupled signalling unit that triggers a calcium signal, which is turned on by stimulating D1 and D2 dopamine receptors. Unlike other dopamine receptors, this novel unit will only create brain signals when both receptors are stimulated at the same time.
Using animal models. Drs. George and O'Dowd and their team identified this complex by its unique reaction to dopamine or specific drug triggers. Strikingly, stimulating this target with dopamine or specific drugs triggered a rise in calcium in the brain. As calcium has a profound effect on almost all brain function, this rise in calcium causes a cascade of events in the brain. This is the first time that a direct connection between dopamine and calcium signals has been reported.
"This distinct unit provides a novel signalling pathway through which dopamine can impact the function of brain cells", said Dr. George. "This is significant because signalling through calcium release is a major mechanism regulating many important functions in the brain and we have provided the first direct mechanism by which dopamine can activate a calcium signal."
This data has significant implications for schizophrenia. Research tells us that people with schizophrenia may have disordered calcium signals, and the major treatments for this disease target the dopamine system. Drs. George and O'Dowd state, "our data links these two pieces of evidence, creating better understanding of the disease and opening the door for a new generation of highly specific drugs that may help alleviate the devastating symptoms of schizophrenia." Public release date: 23-Jan-2007
公开发行：2007-1-23
New dopamine brain target discovered
新的多巴胺脑内作用靶点
Potential breakthrough for schizophrenia treatment
精神分裂症治疗的突破点
Toronto, ON, January 23, 2007 ?A team of Canadian researchers, lead by Dr. Susan
George and Dr. Brian O'Dowd at the Centre for Addiction and Mental health (CAMH),
discovered a distinct dopamine signalling complex in the brain. Composed of two different types of dopamine receptors, this novel target may have a significant role in understanding and treating schizophrenia.
2007年1月23日多伦多--心理卫生和药物成瘾性研究中心(CAMH)Susan George博士和Brian O'Dowd博士带头的加拿大研究小组最新发现大脑中一特定的多巴胺信号络合物。由两种不同的多巴胺受体共同构成，这种新型靶点对深入了解和治疗精神分裂症具有重要的意义。
Published in the Proceedings of the National Academy of Sciences USA (Rashid et al., 2007), this important discovery demonstrates the existence of a Gq/11-coupled signalling unit that triggers a calcium signal, which is turned on by stimulating D1 and D2 dopamine receptors. Unlike other dopamine receptors, this novel unit will only create brain signals when both receptors are stimulated at the same time.
美国国家科学院学报(Rashid等，2007)刊登到，该项发现进一步证实存在能触发钙离子信号的Gq/11双信号通路，该通路又因兴奋D1和D2多巴胺受体而被激活。和其他多巴胺受体不同，该通路必须要同时兴奋D1和D2多巴胺受体才能产生大脑功能信号。
Using animal models. Drs. George and O'Dowd and their team identified this complex by its unique reaction to dopamine or specific drug triggers. Strikingly, stimulating this target with dopamine or specific drugs triggered a rise in calcium in the brain. As calcium has a profound effect on almost all brain function, this rise in calcium causes a cascade of events in the brain. This is the first time that a direct connection between dopamine and calcium signals has been reported.
通过动物实验，George和O'Dowd以及他们的团队根据多巴胺或特定药物触发这种络合物产生独特的反应鉴定出其具体成分。令人惊奇的是，多巴胺或特定药物兴奋这个靶点后引起大脑中钙离子增加。由于钙离子会影响绝大部分的脑功能，钙升高则导致一系列脑部事件发生。目前这是第一次报道多巴胺和钙离子信号之间有直接联系。
"This distinct unit provides a novel signalling pathway through which dopamine can impact the function of brain cells", said Dr. George. "This is significant because signalling through calcium release is a major mechanism regulating many important functions in the brain and we have provided the first direct mechanism by which dopamine can activate a calcium signal."
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作者:admin@医学,生命科学 2011-02-24 05:11
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