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【Nature】推介论文：内皮细胞对肿瘤的抑制作用
http://www.nature.com/nature/journal/v469/n7331/full/469447b.html
Tumours rely on the blood vessels that permeate them to survive. However, secretions from the endothelial-cell lining that supports these vessels blunt tumour growth and spread.
Elazer Edelman at the Massachusetts Institute of Technology in Cambridge and his colleagues studied the effect of endothelial cells, which are abundant in tumours, on human breast- and lung-cancer cells. Those grown in media previously occupied by human endothelial cells exhibited a 40% reduction in growth and were also less invasive. Knocking down a key protein expressed by endothelial cells lowered their ability to block tumour invasion.
Similar anti-tumour effects were seen when the endothelial cells were implanted in mice.
原文
J. W. Franses, A. B. Baker, V. C. Chitalia, E. R. Edelman. 2011. Stromal Endothelial Cells Directly Influence Cancer Progression. Sci. Transl. Med. 3, 66ra5 (2011). 求全文~~ 医药生命科学动态跟踪 - 丁香园论坛 - 医学/药学/生命科学论坛丁香园论坛-医学/药学/生命科学论坛 医药生命科学动态跟踪 super19830102 【哲学版活... 【Science】新西兰生物多样性的崩溃 【Nature】推介论文:内皮细胞对肿瘤的抑制作用 ...news.dxy.cn/-16小时前-快照-医药生命科学动态跟踪 - 丁香园论坛 - 医学/药学/生命科学论坛" 中国大陆医疗科技之现况文件类型:PDF/Adobe Acrobat- 文字版生长的有效代谢物,为神经胶质瘤及其他肿瘤的治疗带来新的曙光. 4 《科学》为该论文... 是一种具有广泛生物学活性的细胞因数,几乎作用於所 有细胞,控制细胞的一系列生命活动....www.ktli.org.tw/...ain7-13.pdf-2011-01-18-乙烯基吡咯烷酮(NVP)和聚乙烯吡咯烷酮(PVP)生产项目文件类型:DOC/Microsoft Word- 文字版联系地址:厦门大学生命科学学院 养生堂北京万泰生物药业有限公司 联系人:夏宁邵(厦门... 人PEX蛋白能拮抗肿瘤血管形成中的生物分子、显著抑制肿瘤血管内皮细胞和肿瘤细胞增...www.xiangankj.gov.cn/...推介.doc-2011-01-20-[标签:content2]
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作者:admin@医学,生命科学 2011-02-05 12:47
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