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【medical-news】不耐受谷氨酸人群结核病发病风险
People who are gluten intolerant run four times the risk of developing active tuberculosis (T infection, suggests research published ahead of print in Thorax.
Gluten intolerance, or coeliac disease, is a chronic inflammatory condition of the small bowel, caused by an exaggerated immune response to the gluten found in wheat, barley, and rye.
It affects up to 1% of the population, and has been linked to several autoimmune diseases, as well as an increased likelihood of lymph gland cancer and complications of pregnancy.
The researchers analysed Swedish hospital discharge records from 1964 to 2003, looking for diagnoses of coeliac disease and TB.
During this period, more than 15,500 people were diagnosed with coeliac disease, almost a third of whom had been diagnosed as adults.
The final analysis was based on 14,335 people, who were compared with almost 70,000 other people, who were free of the disease.
A prior diagnosis of coeliac disease almost quadrupled the chances of active TB infection in both sexes, overall, while a diagnosis in childhood tripled the chances.
In a separate analysis, the researchers looked at the risk of subsequently developing coeliac disease after a diagnosis of TB in the same group of people.
This showed that a prior diagnosis of TB more than doubled the risks of coeliac disease.
The link between TB and gluten intolerance was not influenced by levels of poverty or deprivation with which TB is normally associated.
Poor intake of vitamin D and calcium in people with gluten intolerance as a result of both intestinal malabsorption and the nutritional deficiencies of a gluten free diet, may help to explain the findings, suggest the authors.
Vitamin D is a key player in marshalling the immune response against TB infection. 大致能看懂，但不是我熟悉的专业，让高人来翻译吧 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Gluten Intolerance Quadruples Susceptibility To Tuberculosis
谷氨酸不耐受人群结核病发病风险是正常人的4倍
People who are gluten intolerant run four times the risk of developing active tuberculosis (T infection, suggests research published ahead of print in Thorax.
据《胸腔》杂志发表的研究结果，谷氨酸不耐受人群发生活动性结核（TB）的风险是正常人的4倍。
Gluten intolerance, or coeliac disease, is a chronic inflammatory condition of the small bowel, caused by an exaggerated immune response to the gluten found in wheat, barley, and rye.
谷氨酸不耐受症，又称乳糜泻（CD），是一种由于免疫系统对小麦、大麦和裸麦中的麸质过度反应导致的小肠慢性炎性疾病。
It affects up to 1% of the population, and has been linked to several autoimmune diseases, as well as an increased likelihood of lymph gland cancer and complications of pregnancy.
发病率为1%，与多种自身免疫性疾病的发生有关，增加淋巴系统肿瘤和妊娠并发症的发生率。
The researchers analysed Swedish hospital discharge records from 1964 to 2003, looking for diagnoses of coeliac disease and TB.
研究分析了1964年到2003年间，从瑞典医院出院的CD和TB患者。
During this period, more than 15,500 people were diagnosed with coeliac disease, almost a third of whom had been diagnosed as adults.
发现在这个期间，超过15500名被诊断为CD患者，约占全国CD患者的1/3。
The final analysis was based on 14,335 people, who were compared with almost 70,000 other people, who were free of the disease.
研究分析了14335名CD患者和70000名对照。
A prior diagnosis of coeliac disease almost quadrupled the chances of active TB infection in both sexes, overall, while a diagnosis in childhood tripled the chances.
谷氨酸不耐受人群发生活动性结核的风险是正常人的4倍，是儿童的3倍。且没有性别差异。
In a separate analysis, the researchers looked at the risk of subsequently developing coeliac disease after a diagnosis of TB in the same group of people.
在一项独立分析中，研究者也探讨了TB人群既而发生CD的风险。
This showed that a prior diagnosis of TB more than doubled the risks of coeliac disease.
TB人群发生CD的风险超过正常人的2倍。
The link between TB and gluten intolerance was not influenced by levels of poverty or deprivation with which TB is normally associated.
TB和CD共病不受TB常见相关因素，如贫穷和营养不良的影响。
Poor intake of vitamin D and calcium in people with gluten intolerance as a result of both intestinal malabsorption and the nutritional deficiencies of a gluten free diet, may help to explain the findings, suggest the authors.
谷氨酸不耐受症，引起小肠吸收不良和食用无谷胶饮食造成营养缺乏，最终导致的维生素D和钙摄入不足，有助于解释研究结果。
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作者:admin@医学,生命科学 2011-02-16 17:11
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