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【科普】性行为前请不要吸烟
Sperm don’t like a cigarette before sex
A Canadian genetics study has shown that smoking may damage a man’s sperm, which can be detrimentally passed along to offspring.
Lead investigator Carole L. Yauk, of Health Canada’s Environmental and Occupational Toxicology Division, states that smoking in men can permanently change the DNA of sperm cells, which causes irreversible changes in the genetic composition of their offspring.
DNA, or deoxyribonucleic acid, is the substance—specifically, a nucleic acid molecule with a twisted double strand double helix form—that carries the genetic information for humans and other living organisms from one generation to the next.
Tauk and her collaborators from Health Canada and McMaster University have their results (“Mainstream Tobacco Smoke Causes Paternal Germ-Line DNA Mutation”) published in this week’s issue of the scientific journal Cancer Research (2007 67: 5103-5106). Martin R. Stämpfli led the team from McMaster University. Other collaborators include M. Lynn Berndt, Andrew Williams, Andrea Rowan-Carroll, and George R. Douglas.
The article’s abstract appears at the Cancer Research website.
Within their study, the researchers used spermatogonial stem cells (those stem cells that constantly produce sperm in all mammals) and exposed them to cigarette smoke for six or 12 weeks. The mice were exposed to two cigarettes per day, which is equivalent to the amount taken in by an average human that smokes.
A control group was not exposed to the smoke. Their results show that the mice exposed to the smoke—for 12 weeks—were 1.7 times more likely to have DNA mutations than the mice not exposed to smoke. The mice exposed for six weeks were 1.4 times more likely to have mutations than the control group of mice.
They conclude that the longer the male mice were exposed to cigarette smoke the more damage that accumulates within sperm and the more likely genetic mutations will occur in offspring.
Tauk emphasized the fact that it has been previously known that mothers who smoke during their pregnancies can harm their fetuses. This study adds more evidence to the detrimental effects of cigarette smoke on offspring from men smoking even before their offspring are produced.
Yauk and her collaborators plan to learn more about this relationship as they study how the modified DNA reacts in the first-generation and second-generation offspring of the studied mice, both with respect to firsthand and secondhand smoke. 本人认领此文. 如在48小时内未能提交译文, 其他战友自由认领. 563字
Sperm don’t like a cigarette before sex
性行为前请勿吸烟
A Canadian genetics study has shown that smoking may damage a man’s sperm, which can be detrimentally passed along to offspring.
加拿大一项遗传学研究表明，吸烟可能损害男性精子，不利于其后代。
Lead investigator Carole L. Yauk, of Health Canada’s Environmental and Occupational Toxicology Division, states that smoking in men can permanently change the DNA of sperm cells, which causes irreversible changes in the genetic composition of their offspring.
加拿大环境和职业毒理学分部首席研究员Carole L. Yauk称，男性吸烟可以造成精子细胞DNA永久性改变，从而导致吸烟者后代遗传组成的不可逆性变化。
DNA, or deoxyribonucleic acid, is the substance—specifically, a nucleic acid molecule with a twisted double strand double helix form—that carries the genetic information for humans and other living organisms from one generation to the next.
DNA即脱氧核糖核酸，是一种双螺旋链核酸分子，它携带人类及其他生物的遗传信息，使其代代相传。
Tauk and her collaborators from Health Canada and McMaster University have their results (“Mainstream Tobacco Smoke Causes Paternal Germ-Line DNA Mutation”) published in this week’s issue of the scientific journal Cancer Research (2007 67: 5103-5106). Martin R. Stämpfli led the team from McMaster University. Other collaborators include M. Lynn Berndt, Andrew Williams, Andrea Rowan-Carroll, and George R. Douglas.
Tauk及其来自加拿大McMaster大学的同事在本周《癌症研究》杂志中发表了她们的论文《主流吸烟导致父系精子DNA突变》。Martin R. Stämpfli是McMaster大学研究小组的带头人，其他成员包括M. Lynn Berndt、Andrew Williams、 Andrea Rowan-Carroll及 George R. Douglas。
The article’s abstract appears at the Cancer Research website.
在《癌症研究》网页上可以查阅此论文摘要。
Within their study, the researchers used spermatogonial stem cells (those stem cells that constantly produce sperm in all mammals) and exposed them to cigarette smoke for six or 12 weeks. The mice were exposed to two cigarettes per day, which is equivalent to the amount taken in by an average human that smokes.
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作者:admin@医学,生命科学 2011-02-13 05:11
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