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【medical-news】一天一次来得时效果堪比一日三次
LONDON (Reuters) - A once-daily injection of Sanofi-Aventis's insulin drug Lantus controls blood sugar as effectively as Eli Lilly's Humalog, which needs to be taken three times daily, researchers said on Friday.
The study of 418 people with type 2 diabetes in 69 sites across Europe and Australia also found that Lantus was associated with a lower risk of potentially dangerous low blood sugar level.
The researchers reported their findings in the journal Lancet.
"We conclude that (Lantus) provides a simple and effective option that is more satisfactory to patients than is (Humalog) for early initiation of insulin therapy," Reinhard Bretzel of Justus-Liebig-Universitat in Germany and colleagues wrote.
Diabetes is a condition in which a person's blood glucose levels are too high. Too much glucose in the blood can damage the eyes, kidneys and nerves, and lead to heart disease, stroke and limb amputations.
Type 2 diabetes is the form closely linked to obesity.
Insulin treatments aim to limit glucose, or blood sugar, level without causing it to fall so low that it could cause hypoglycaemia -- a condition marked by tremors and nausea that in extreme cases can kill.
During the 44-week trial researchers randomly assigned volunteers to receive one of the types of injections. Lantus reduced blood sugar levels to 7 percent from 8.7 percent while the average Humalog decrease was to 6.8 percent from 8.7 percent, the study found.
Doctors target concentrations of less than 7 percent to reduce the risk of blindness, kidney problems and gangrene, the researchers added.
Rates of hypoglycaemia were also lower for people using Lantus, amounting to 5.2 patients per year compared to 24 patients per year with Humalog, the researchers said.
An additional benefit, the Sanofi-funded study showed, was that Lantus patients were more satisfied with their treatment, likely because of the convenience of fewer daily injections, the researchers said.
"Study participants taking (Lantus) reported greater overall treatment satisfaction, with specific improvements in convenience of treatments," the researchers wrote. 本人已认领该文编译，24小时后若未提交译文，请其他战友自由认领。 Sanofi's Lantus insulin favored over rival: study
赛诺菲的来的时胰岛素与对手匹敌：研究
LONDON (Reuters) - A once-daily injection of Sanofi-Aventis's insulin drug Lantus controls blood sugar as effectively as Eli Lilly's Humalog, which needs to be taken three times daily, researchers said on Friday.
伦敦（路透通讯社） 研究者周五说，一天一次注射赛诺菲胰岛素制剂来的时与礼来的一天三次的优泌林控制血糖作用相当。
The study of 418 people with type 2 diabetes in 69 sites across Europe and Australia also found that Lantus was associated with a lower risk of potentially dangerous low blood sugar level.
这项对418名2型糖尿病患者的研究跨越欧洲和澳大利亚69个地点，同时发现来的时患潜在低血糖的危险更低。
The researchers reported their findings in the journal Lancet.
研究者在柳叶刀杂志报道了他们的发现。
"We conclude that (Lantus) provides a simple and effective option that is more satisfactory to patients than is (Humalog) for early initiation of insulin therapy," Reinhard Bretzel of Justus-Liebig-Universitat in Germany and colleagues wrote.
德国Justus-Liebig大学的Reinhard Bretzel和他的同事写道：“我们总结，对于早期胰岛素的起始治疗，来的时比优泌林提供了一个简单有效的更令人满意的选择。
Diabetes is a condition in which a person's blood glucose levels are too high. Too much glucose in the blood can damage the eyes, kidneys and nerves, and lead to heart disease, stroke and limb amputations.
糖尿病是病人血糖水平太高的一种状况。血液中太多的血糖会损害眼睛、肾脏和神经，也导致心脏疾病、中风和截肢。
Type 2 diabetes is the form closely linked to obesity.
2型糖尿病是与肥胖紧密相连的一种形式。
Insulin treatments aim to limit glucose, or blood sugar, level without causing it to fall so low that it could cause hypoglycaemia -- a condition marked by tremors and nausea that in extreme cases can kill.
胰岛素治疗目标是限制葡萄糖或者说血糖水平，且不会降到太低以至发生低血糖－一种以颤抖和恶心为标志的状况，极端时可导致死亡。
During the 44-week trial researchers randomly assigned volunteers to receive one of the types of injections. Lantus reduced blood sugar levels to 7 percent from 8.7 percent while the average Humalog decrease was to 6.8 percent from 8.7 percent, the study found.
在历时44周的试验中，研究者把志愿者随机分派接受任何一种注射方法。研究发现，来的时把低血糖从平均8.7降到7的水平，优泌林则把血糖从平均8.7降到6.8的水平。
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作者:admin@医学,生命科学 2010-12-17 07:31
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