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【bio-news】具有多种再生潜能的多能干细胞来源被
ScienceDaily (Sep. 24, 2008) — In a promising finding for the field of regenerative medicine, stem cell researchers at Children's Hospital of Pittsburgh of UPMC have identified a source of adult stem cells found on the walls of blood vessels with the unlimited potential to differentiate into human tissues such as bone, cartilage and muscle.
The scientists, led by Bruno Péault, PhD, deputy director of the Stem Cell Research Center at Children's Hospital, identified cells known as pericytes that are multipotent, meaning they have broad developmental potential. Pericytes are found on the walls of small blood vessels such as capillaries and microvessels throughout the body and have the potential to be extracted and grown into many types of tissues, according to the study.
"This finding marks the first direct evidence of the source of multipotent adult stem cells known as mesenchymal stem cells. We believe pericytes represent one of the most promising sources of multipotent stem cells that scientists have been searching for in the quest to make regenerative medicine possible," Dr. Péault said. "The encouraging aspect of this source is that blood vessels are the one structure that all tissues in the human body have in common. These cells can be extracted easily and painlessly from convenient sources such as fat tissue, dental pulp, umbilical cord and placental tissue, then grown in culture to large numbers and, possibly, re-injected into the patient to heal a broken bone, a failing joint or an injured muscle."
In their laboratory in the John G. Rangos Sr. Research Center, researchers were able to identify pericytes in all human tissues they analyzed, including muscle, fat, pancreas, placenta and many other samples. Through purification in the lab, these pericytes could then be coaxed into becoming whatever type of tissue the scientists desired. For instance, the researchers took pericytes from the pancreas and then reinjected them into an injured muscle. The cells immediately began regenerating muscle tissue.
Results of the study are published in the September issue of the journal Cell Stem Cell.
http://www.sciencedaily.com/releases/2008/09/080922122429.htm 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 Source Of Multipotent Stem Cells With Broad Regenerative Potential identified
具有多种再生潜能的多能干细胞来源被确定
ScienceDaily (Sep. 24, 2008) — In a promising finding for the field of regenerative medicine, stem cell researchers at Children's Hospital of Pittsburgh of UPMC have identified a source of adult stem cells found on the walls of blood vessels with the unlimited potential to differentiate into human tissues such as bone, cartilage and muscle.
再生医学领域有一项有意义的发现，来自于匹兹堡大学医学中心(UPMC)儿童医院的干细胞研究人员鉴定了一种血管壁来源的成体干细胞，具有分化成多种人体组织如：骨，软骨和肌肉的无限潜能。
The scientists, led by Bruno Péault, PhD, deputy director of the Stem Cell Research Center at Children's Hospital, identified cells known as pericytes that are multipotent, meaning they have broad developmental potential.
儿童医院干细胞研究中心的副主任Bruno Péault博士领导的科学家团队,鉴定出已知的周细胞pericytes，有多向分化潜能，意思是有广泛的各种组织分化能力。
Pericytes are found on the walls of small blood vessels such as capillaries and microvessels throughout the body and have the potential to be extracted and grown into many types of tissues, according to the study.
根据这项研究：周细胞分布要全身如毛细胞血管和微血管的小血管壁上，有可能分离出并培养成多种组织。
"This finding marks the first direct evidence of the source of multipotent adult stem cells known as mesenchymal stem cells. We believe pericytes represent one of the most promising sources of multipotent stem cells that scientists have been searching for in the quest to make regenerative medicine possible," Dr. Péault said. "The encouraging aspect of this source is that blood vessels are the one structure that all tissues in the human body have in common. These cells can be extracted easily and painlessly from convenient sources such as fat tissue, dental pulp, umbilical cord and placental tissue, then grown in culture to large numbers and, possibly, re-injected into the patient to heal a broken bone, a failing joint or an injured muscle."
Péault 博士说：“这个发现是标志存在多潜能成体干细胞（已知的间充质干细胞）第一个直接证据。我们相信周细胞代表了最有意义的多能干细胞，正是科学家为使再生医学成功而一直在寻找的细胞，更有利的一方面是该细胞来源于血管壁，这在人体中所有组织都有。能比较容易和无痛的从方便的来源如脂肪组织，牙髓，脐血和胎盘组织中分离，然后大量培养，并有可能重新回注入患者治愈骨折，受损的关节或损伤的肌肉。”
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作者:admin@医学,生命科学 2010-09-23 05:11
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