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【medical-news】术中防止肿瘤细胞伤口种植
When colon cancer tumor cells are exposed to high pressure they exhibit an increased ability to stick to other cells. In the study, to mimic the conditions of surgery, the authors removed colon cancer cells from one mouse, exposed them to high pressure in vitro, and then transplanted them into a second mouse that they monitored for the development of tumors at the site of the surgical wound. The most important observation made was that if the mice from which the colon cancer cells came from were treated perioperatively with colchicine there was a dramatic decrease in the number of tumors that formed at the site of the surgical wound in the second mouse. As in vitro exposure of tumor cells from breast and head and neck cancers to high pressure also increases their ability to stick to other cells it is possible that these data might have implications in several clinical settings. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Sometimes during surgery to remove a tumor, cells become detached from the bulk of the tumor. In a small number of cases, these tumor cells stick to cells at the site of the surgical wound and go on to form a secondary tumor, having an enormous negative impact on the survival and quality of life of the patient.
有时在肿瘤的切除手术中，肿瘤细胞从较大包块中被分离出来。在较少数的病例中，这些肿瘤细胞黏附造手术切口附近的细胞上继而发展成为继发肿瘤，对手术和病人的生活质量有巨大的负面影响。[/color]
New data, generated by Marc Basson and colleagues, at the John D. Dingell VA Medical Center and Wayne State University, Detroit, using a mouse model of surgery to remove a colon cancer tumor, suggest that perioperative treatment with a drug known as colchicine might decrease the incidence of tumor formation at the site of the surgical wound.
[color=purple]最新的数据，是由来自Detroit市韦恩州立大学John D. Dingell VA 医疗中心的Marc Basson及其他的同僚们，使用患有结肠癌的小鼠外科手术模型，他们建议在围手手术期间使用秋水仙素可能减少手术切口部位的肿瘤形成的几率。 编译：
有时在肿瘤的切除手术中，肿瘤细胞从较大包块中被分离出来。在较少数的病例中，这些肿瘤细胞黏附造手术切口附近的细胞上继而发展成为继发肿瘤，对手术和病人的生活质量有巨大的负面影响。
最新的数据，是由来自Detroit市韦恩州立大学John D. Dingell VA 医疗中心的Marc Basson及其他的同僚们，使用患有结肠癌的小鼠外科手术模型，他们建议在围手手术期间使用秋水仙素可能减少手术切口部位的肿瘤形成的几率。
当结肠癌细胞被暴露在高压环境中会表现出吸附于其他细胞的能力的增强。在研究中的模仿外科手术条件下，笔者从一只小鼠移出结肠癌细胞，将其在试管内暴露在高压环境中，（接着）他们将其移植到另外一只小鼠中并观察肿瘤细胞在外科手术切口处的发展。
这个最重要的观察结果是被移植结肠癌细胞的小鼠在手术后治疗中使用秋水仙素是否能够抑制肿瘤在外科手术切口处的生长。当那些来自胸部、头部、颈部癌症的肿瘤细胞在试管内高压（环境后），同样能够提高他们对其他细胞的黏附能力，这些数据可能与一些临床情况相联系。 在第二段中的 perioperative treatment 应译作 在围手手术期更确切一些？
shoushudao11 wrote:
在第二段中的 perioperative treatment 应译作 在围手手术期更确切一些？
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作者:admin@医学,生命科学 2011-08-12 05:30
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