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科学家发现7种新的糖尿病基因
详细内容编译请参见
http://www.nytimes.com/2007/04/27/us/27diabetes.html?ex=1335326400&en=5168a558ebf7fde0&ei=5088&partner=rssnyt&emc=rss
纽约时报提到：
“Having done neurological research at the University of Chicago and Harvard, Dr. Stefansson is no stranger to the sharp elbows sometimes wielded in biomedical research, and indeed is not without a good pair of his own. He said his report last year on an important new diabetes gene, known as TCF7L2, had been rejected by both Nature and Science, two leading scientific journals, because of negative reports from his competitors, and he chided Science for now publishing reports on genes of lesser effect from the same people. Dr. Stefansson’s paper on TCF7L2 was published in March 2006 in Nature Genetics.
A spokeswoman for Science declined to comment on whether the journal had rejected Dr. Stefansson’s earlier paper. 本人以认领该文编译，48小时内若未提交译文，请其他战友自由认领 Scientists Identify 7 New Diabetes Genes
科学家发现7种新的糖尿病基因
Published: April 27, 2007 发表时间：2007年4月27 日
Researchers said yesterday that they had identified seven new genes connected to the most common form of diabetes — the latest result of an intensifying race between university researchers and private companies to find genes linked to a range of diseases.
昨天，研究者们宣称他们已经发现了7种新的基因与最常见类型糖尿病相关。这是大学研究员与私人公司在寻找疾病相关基因的激烈竞赛中最新的结果。
The findings, presented in three reports by university scientists and one by a private company, offer novel insights into the biology of a disease that affects 170 million people worldwide.
大学科学家发表了3篇有关此发现的报告，私人公司也有1篇相关报告。此发现为影响着全世界1.7亿人健康的疾病的相关生物学提供新的认识点。
And the sudden spate of new results mark an acceleration, and perhaps a turning point, in the ability to find disease genes, the long-promised payoff from the human genome project that began in 1989.
这个突然的新发现标志着寻找疾病相关基因能力的提高，也可能是其中一个转折点，是1989年开始的人类基因组计划希望的长远结果。
Yesterday’s reports bring the number of well-attested genes involved in adult-onset, or Type 2 diabetes up to 10, from the 3 known previously. The new genes do not immediately suggest any new therapy, but may point to a new biological basis for the disease, from which effective treatments could emerge in time.
昨天的报告带来了大量得到很好证实的成人型或2型糖尿病相关基因。数目由过去的3个增加到现在的10个。新发现的相关基因并没有立即给出新的有关治疗，但可为糖尿病提供新的生物学基础，从而能及时研究出有效的治疗方法。
DeCode Genetics, an Icelandic company responsible for one of the reports, has dominated the gene-finding field for the last five years. The other papers come from three academic consortiums led by Dr. David Altshuler of the Broad Institute, Michael Boehnke of the University of Michigan and Mark McCarthy of the University of Oxford in England.
发表了其中一篇相关报告的冰岛一家遗传解码公司（DeCode Genetics）在寻找疾病相关基因领域已经有5年的优势。另外3篇论文分别是由学院派的麻省理工学院Broad 研究所的Dr. David Altshuler教授，密歇根大学的Michael Boehnke教授和英国牛津大学的Mark McCarthy 教授带领下发表的。
DeCode Genetics has been the first to find several major disease genes through skillful analysis of the Icelandic patient population and its well-documented health care system. Its academic competitors, with the support of the National Institutes of Health, have had to describe and analyze the much wider range of genetic variation in the American and European populations. This has required analyzing 10 million SNPs (pronounced snips), or sites of common genetic variation on the human genome, and cataloging them in a project known as the HapMap.
遗传解码公司通过对冰岛病患巧妙的分析和良好的卫生保健制度最先发现了几个主要疾病相关基因。他的学院派竞争者在国立卫生研究院（NIH）的支持下，必须描述和分析更宽范围的美国和欧洲人的遗传变异。这就需要分析1千万单核苷酸多态性（SNPs） (显著剪去),或人类基因组共同的遗传变异位点，并把它们编录到一个叫HapMap的设计中。
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作者:admin@医学,生命科学 2011-06-20 23:45
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