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【转贴】最新研究表明，paclitaxel对早老性痴呆症
【原文】http://www.angiotech.com/?seeknamed=News%20index&viewpr=526&PHPSESSID=d8b932f4c27b81fb5be52ff0a9d5cce3
【published】VANCOUVER, Dec 22, 2004 (Canada NewsWire via COMTEX)
Angiotech制药公司今天宣称，根据一份今天由国家科学院（NAS）发布的一份报告称，临床前研究表明，PAXCEED对于运动紊乱症（如早老性痴呆，帕金森氏症）显示出良好的效果。
该研究结果显示，在模型动物身上注射paclitaxel（即：PAXCEED）后表现出了对神经功能的保护作用。研究中，低剂量（10 mg/m2）和中等剂量（25mg/m2）的PAXCEED有两方面的效果：1、改善轴突的传导；2、增加对神经结构和功能至关重要的微管蛋白、蛋白、以及细胞等。
ngiotech公司CEO，医学博士William Hunter先生说：“我们很高兴paclitaxel在先期试验中的这些作用，这说明我们有望将该药物发展开发成为一种用于老年性痴呆症和其他神经系统疾病的新药。我们确信，微管稳定性药物的使用一定能够微这些疾病的治疗起到积极的效果，我们对下一步在人体的研究结果充满了期待。”
Angiotech Pharmaceuticals, Inc. (NASDAQ: ANPI; TSX: ANP), today announced that a preclinical study published in today's early edition of the Proceedings of the National Academy of Sciences highlights the positive effects of PAXCEED™ on movement disorders commonly seen in diseases known as taupathies, such as Alzheimer's and Parkinson's.
Results from the study reveal that injected paclitaxel (PAXCEED™) appear to restore nerve function in an animal model. In the study, it was demonstrated that low (10mg/m2) and medium (25mg/m2) doses of PAXCEED™ had two major effects: 1) improving axonal transport and 2) increasing the amounts of tubulin and microtubules, proteins and cell structures vital for nerve structure and conduction.
"We are excited as this is the first experimental evidence to support the use of paclitaxel as a novel intervention for the treatment of Alzheimer's and other neurodegenerative diseases," said William Hunter, MD, CEO of Angiotech."We have long believed that a microtubule stabilizing agent used systemically would hold great promise in these types of diseases, and we look forward to advancing the results of these studies into humans."
Abnormal tau proteins are often seen as mechanisms that can lead to brain degeneration in Alzheimer's disease and other neurodegenerative disorders known as taupathies. In all taupathies, there are neuropathologic aggregates of paired helical filaments and/or straight filaments composed of aberrantly phosphorylated tau proteins in central nervous system neurons or glia. It has been shown that these abnormally filamentous proteins cannot perform the important functions of binding and stabilizing microtubules which often leads to a dramatic increase in neurofibrillary tangles and neuropil threads seen in Alzheimer's. Angiotech believes that systemic paclitaxel (PAXCEED™), a microtubule stabilizing agent, may ultimately show a therapeutic benefit to patients with Alzheimer's disease and other taupathies by offsetting the loss of normal tau function.
Vancouver-based Angiotech Pharmaceuticals, Inc., a specialty pharmaceutical company focusing on drug-eluting medical devices and biomaterials, is dedicated to enhancing the performance of medical devices and biomaterials through the innovative uses of pharmacotherapeutics. To find out more about Angiotech Pharmaceuticals, Inc. (NASDAQ: ANPI, TSX: ANP), visit our website at www.angiotech.com.
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作者:admin@医学,生命科学 2011-06-15 05:20
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