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【文摘发布】个体患者资料的meta分析：非小细胞
Lancet Oncology 2007; 8:488-499
DOI:10.1016/S1470-2045(07)70145-6
Articles
TITLE: Microvessel density as a prognostic factor in non-small-cell lung carcinoma: a meta-analysis of individual patient data
Marialena Trivella DPhil, Francesco Pezzella MD, Ugo Pastorino MD, Prof Adrian L Harris FRCP and Prof Douglas G Altman DSc, for the Prognosis In Lung Cancer (PILC) Collaborative Study Group
Summary
Background
Angiogenesis is a potential prognostic factor that has been investigated in patients with non-small-cell lung carcinoma. However, published studies of the role of angiogenesis as a prognostic factor are inconclusive. We aimed to collect individual patient data to assess microvessel-density counts (ie, a measure of angiogenesis) as a prognostic factor in non-small-cell lung carcinoma.
Methods
We obtained published and unpublished datasets and extracted appropriate data, taking particular care to ensure data quality. Detailed information was obtained for the laboratory methods used by every research centre that generated the data. The outcome of interest was overall survival. We did a meta-analysis to estimate the prognostic role of microvessel density by combining separately estimated hazard ratios (HR) from every study, which were adjusted for tumour stage and age. Analyses were done separately for studies that used the Chalkley method or for those that counted all microvessels.
Findings
17 centres provided data for 3200 patients, 2719 of which were included in the analysis. All but three centres (datasets 9, 10, and 13–367 cases) had already published their findings, and six had updated follow-up information (datasets 1, 2, 3, 6, 7, and 8–1273 cases). For all but three centres (datasets 4, 11, and 13) some data corrections were necessary. For microvessel density counts obtained by the Chalkley method, the HR for death per extra microvessel was 1·05 (95% CI 1·01–1·09, p=0·03) when analysed as a continuous variable. For microvessel density counts obtained by the all vessels method, the HR for death per ten extra microvessels was 1·03 (0.97–1·09, p=0·3) when analysed as a continuous variable.
Interpretation
Microvessel density does not seem to be a prognostic factor in patients with non-metastatic surgically treated non-small-cell lung carcinoma. This conclusion contradicts the results of a meta-analysis of published data only. Therefore, the methodology used to assess prognostic factors should be assessed carefully. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 The Lancet Oncology, Current Issue, Volume 8, Number 6, June 2007
柳叶刀肿瘤分册，现期杂志，第八卷，第六期，2007.6
Lancet Oncology 2007; 8:488-499
柳叶刀肿瘤分册.2007；8：488-499
DOI:10.1016/S1470-2045(07)70145-6
标识码:10.1016/S1470-2045(07)70145-6
Articles
论著
TITLE: Microvessel density as a prognostic factor in non-small-cell lung carcinoma: a meta-analysis of individual patient data
题目：个体患者资料的meta分析：非小细胞肺癌的预后因子微血管密度
Marialena Trivella DPhil, Francesco Pezzella MD, Ugo Pastorino MD, Prof Adrian L Harris FRCP and Prof Douglas G Altman DSc, for the Prognosis In Lung Cancer (PILC) Collaborative Study Group
作者：Marialena Trivella DPhil, Francesco Pezzella MD, Ugo Pastorino MD, Prof Adrian L Harris FRCP and Prof Douglas G Altman DSc
作者单位：肺癌预后研究合作组(PILC)
Summary
概要
Background
背景
Angiogenesis is a potential prognostic factor that has been investigated in patients with non-small-cell lung carcinoma. However, published studies of the role of angiogenesis as a prognostic factor are inconclusive. We aimed to collect individual patient data to assess microvessel-density counts (ie, a measure of angiogenesis) as a prognostic factor in non-small-cell lung carcinoma.
在已调查过的非小细胞肺癌患者中，血管生成是一个潜在预后因子。但是，已发表的研究对血管形成作为一种预后因子并未给出确定的结论。我们旨在通过收集不同患者资料，从而评价微血管密度计数(如血管形成的测量)是否可在非小细胞肺癌中作为一种预后因子。
Methods
方法
We obtained published and unpublished datasets and extracted appropriate data, taking particular care to ensure data quality. Detailed information was obtained for the laboratory methods used by every research centre that generated the data. The outcome of interest was overall survival. We did a meta-analysis to estimate the prognostic role of microvessel density by combining separately estimated hazard ratios (HR) from every study, which were adjusted for tumour stage and age. Analyses were done separately for studies that used the Chalkley method or for those that counted all microvessels.
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作者:admin@医学,生命科学 2011-04-06 14:04
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