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【medical-news】普通感染增加患COPD风险
Published date :
22 Aug 2008
MedWire News: Mycoplasma pneumoniae (Mp), an infection that often goes undetected, can block the natural protective response of the lung against tobacco smoke, according to US researchers.
The findings could point to a mechanism that may cause smokers to develop chronic obstructive pulmonary disease (COPD), Brian Day and colleagues from the National Jewish Medical & Research Center in Denver, Colorado, explain in the journal Infection and Immunity.
"Although smoking is the overwhelming cause of chronic obstructive pulmonary disease (COPD), only 20% of smokers develop the disease," Day said. "Our findings suggest that Mp infection may be one of the co-factors that lead to COPD and other diseases among smokers."
Chronic cigarette smoking evokes a lung glutathione adaptive response that results in elevated glutathione levels, but previous studies have indicated that lung infections might affect the protective response of the lung. Mp is a common lung pathogen and the most common cause of pneumonia, but can be difficult to detect because it is challenging to grow in culture.
Day and team infected mice with Mp, and found it had a mild effect, slightly lowering glutathione levels in the lungs of mice breathing fresh air. However, mice that were exposed to tobacco smoke and then infected with Mp had significantly reduced glutathione levels.
"The Mp infection completely blocked the protective response mice normally mount against tobacco smoke, reducing antioxidant levels well below even those of mice breathing fresh air," said Day.
In addition, the team found that mice exposed to tobacco smoke and Mp had much higher levels of oxidized glutathione and lower levels of reduced glutathione, along with significantly lowered levels of the enzyme glutathione reductase.
"The Mp infection blocked the lungs' protective response to tobacco smoke by lowering levels of the enzyme that normally recycles oxidized glutathione back into its protective, reduced form," said Day. "This resulted in severe oxidative stress and increased tissue damage as measured by oxidized DNA."
He adds: "These higher levels of oxidative stress and damage are likely to predispose smokers with Mycoplasma infections to lung disease, such as COPD or cancer."
Day concludes: "These studies suggest Mp infection synergizes with ETS and suppresses the lung's ability to respond appropriately to environmental challenges leading to enhanced oxidative stress."
Source :
Current Medicine Group Common infection may increase risk for COPD
普通感染可能增加COPD的风险
Published date :
发表日期：
22 Aug 2008
2008年8月22日
MedWire News: Mycoplasma pneumoniae (Mp), an infection that often goes undetected, can block the natural protective response of the lung against tobacco smoke, according to US researchers.
医学在线新闻：美国研究人员发现，肺炎支原体，一种常未被检出的感染，能阻碍肺对吸烟的自然保护作用。
The findings could point to a mechanism that may cause smokers to develop chronic obstructive pulmonary disease (COPD), Brian Day and colleagues from the National Jewish Medical & Research Center in Denver, Colorado, explain in the journal Infection and Immunity.
科罗拉多州丹佛的杰维斯国家医学研究中心的Brian Day和其同事在感染和免疫杂志中解释，这一发现可能阐明吸烟者患COPD的原因。
"Although smoking is the overwhelming cause of chronic obstructive pulmonary disease (COPD), only 20% of smokers develop the disease," Day said. "Our findings suggest that Mp infection may be one of the co-factors that lead to COPD and other diseases among smokers."
Day说，尽管吸烟是导致慢性阻塞性肺病（COPD）的最主要因素，但是只有20%的吸烟者罹患COPD。我们的发现提示肺炎支原体感染可能是一个协同因素，导致COPD和吸烟引起的其他疾病。
Chronic cigarette smoking evokes a lung glutathione adaptive response that results in elevated glutathione levels, but previous studies have indicated that lung infections might affect the protective response of the lung. Mp is a common lung pathogen and the most common cause of pneumonia, but can be difficult to detect because it is challenging to grow in culture.
慢性吸烟能诱发肺对谷胱甘肽的自适应反应，导致谷胱甘肽水平升高，但先前的研究显示肺部感染可能影响肺的保护反应。肺炎支原体是肺部的常见病原体和最常见的引起肺炎的原因，但不易被发现，因为其在培养基上不易生长。
Day and team infected mice with Mp, and found it had a mild effect, slightly lowering glutathione levels in the lungs of mice breathing fresh air. However, mice that were exposed to tobacco smoke and then infected with Mp had significantly reduced glutathione levels.
Day和其研究小组用肺炎支原体感染小鼠，发现在呼吸新鲜空气的小鼠，其作用微弱，只轻度降低肺谷胱甘肽水平。然而，暴露在吸烟环境下的小鼠感染肺炎支原体后，谷胱甘肽水平明显下降。
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作者:admin@医学,生命科学 2010-09-27 12:36
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