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【medical-news】Blood DNA Can Be Early Predictor Of Liver C
Source: Columbia University's Mailman School of Public Health
Date: April 17, 2007
Blood DNA Can Be Early Predictor Of Liver Cancer
Science Daily — Researchers at Columbia University's Mailman School of
Public Health have discovered a means for early detection of liver cancer.
Using DNA isolated from serum samples as a baseline biomarker, the
scientists examined changes in certain tumor suppressor genes that have been
associated with the development of liver carcinomas. This is the first study
to prospectively examine potential biomarkers for early detection of liver
cancer in high-risk populations, including those with chronic hepatitis B
and C virus infections.
Since most hepatocellular or liver carcinomas (HCC) are diagnosed at an
advanced and usually fatal stage, the development of screening methods for
early detection is critical. HCC is one of the most common and rapidly fatal
human malignancies. Worldwide, the almost 500,000 new cases and nearly
equivalent number of fatalities illustrates the lack of effective
therapeutic alternatives for this disease.
The Mailman School researchers and colleagues studied the blood of patients
enrolled in a cancer screening program in Taiwan, who provided repeated
blood samples prior to diagnosis. A total of 12,000 males and over 11,900
females recruited in 1991-2 are being followed. Screenings performed by the
team of Mailman School scientists found changes associated with cancer in
serum DNA, presumably released from the tumor, one to nine years before
actual clinical diagnosis.
Certain clinical risk factors such as age and hepatitis B and C virus
infections, are well documented risk factors for the development of HCC.
According to the study findings, these factors coupled with smoking and
alcohol status, and alterations found in this study in serum DNA, resulted
in an overall predictive accuracy of 89% for detection of HCC.
"These are extremely encouraging findings," says Regina Santella, PhD,
professor of Environmental Health Sciences at the Mailman School of Public
Health, director of the Columbia's NIEHS Center for Environmental Health in
Northern Manhattan, and principal investigator on the research. "Having the
tools to identify hepatocellular carcinoma at earlier stages, is truly a
breakthrough for addressing the challenges that result from this highly
lethal form of cancer."
Dr. Santella and the team of researchers previously found that several
environmental factors including aflatoxin B1, a dietary mold contaminant
sometimes found in peanuts and corn; polycyclic aromatic hydrocarbons,
ubiquitous environmental contaminants; and 4-aminobiphenyl, a carcinogen
found in cigarette smoke, are also associated with the development of HCC.
While HCC incidence is highest in East Asia and Sub-Saharan Africa, it is
also increasing in the U.S primarily as a result of HCV infection.
"We are not only very excited about what this means in terms of early
detection for hepatocellular cancer but optimistic about how it could also
be applied to other cancers," observes Dr. Santella. The full study findings
are published in the April 15, 2007 issue of Clinical Cancer Research.
Note: This story has been adapted from a news release issued by Columbia
University's Mailman School of Public Health. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Source: Columbia University's Mailman School of Public Health
Date: April 17, 2007
来源：哥伦比亚大学梅尔曼公共卫生学院
发表日期：2007.4.17
Blood DNA Can Be Early Predictor Of Liver Cancer
血液DNA是肝癌的早期预报器
Science Daily — Researchers at Columbia University's Mailman School of Public Health have discovered a means for early detection of liver cancer. Using DNA isolated from serum samples as a baseline biomarker, the scientists examined changes in certain tumor suppressor genes that have been associated with the development of liver carcinomas. This is the first study to prospectively examine potential biomarkers for early detection of liver cancer in high-risk populations, including those with chronic hepatitis B and C virus infections.
每日科学——哥伦比亚大学梅尔曼公共卫生学院的研究人员发现了一种早期检测肝癌的方法。他们将从血液中分离的DNA作为基准的生物标记，检查某种与肝癌发展密切相关的抑癌基因的改变。这是首次研究在高危人群肝癌早期检测中可能的生物标记物，包括那些慢性乙型肝炎病毒和丙型肝炎病毒感染患者。
Since most hepatocellular or liver carcinomas (HCC) are diagnosed at an advanced and usually fatal stage, the development of screening methods for early detection is critical. HCC is one of the most common and rapidly fatal human malignancies. Worldwide, the almost 500,000 new cases and nearly equivalent number of fatalities illustrates the lack of effective therapeutic alternatives for this disease.
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作者:admin@医学,生命科学 2011-03-15 17:12
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