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【medical-news】肺动脉高压患者行经皮房间隔缺损
Objectives: To examine the outcomes in patients with moderate or severe pulmonary arterial hypertension (PAH) undergoing percutaneous atrial septal defect (ASD) closure.
Design: Retrospective study.
Setting: Teaching hospital-based study.
Patients: Fifty-four patients with moderate (n = 34) or severe PAH (n = 20) who underwent successful device implantation between 1999 and 2004 were included in the study. Clinical and transthoracic echocardiographic data were reviewed. Pulmonary hypertension was classified as moderate (50–59 mm Hg) or severe (60 mm Hg) according with the right ventricular systolic pressure (RVSP) calculated by echocardiography.
Results: At the early follow-up (mean (SD) 2.3 (1.2) months) all patients were alive and the baseline RVSP decreased from 57 (11) mm Hg to 51 (17) mm Hg (p = 0.003). At the late follow-up (n = 39, mean (SD) duration 31 (15) months) two patients had died and the baseline RVSP decreased from 58 (10) mm Hg to 44 (16) mm Hg (p = 0.004). Although the overall mean RVSP decreased at late follow-up, only 43.6% (17/39) of patients had normalisation (<40 mm Hg) of the RVSP and 15.4% (6/39) had persistent severe PAH.
Conclusion: Transcatheter closure in patients with secundum ASD and PAH can be successfully performed in selected subjects and is associated with good outcomes. Early improvements in RVSP are seen in patients with moderate or severe PAH undergoing transcatheter ASD closure. Continued improvement in RVSP occurs in late follow-up. Despite decreases in the mean RVSP in late follow-up, many patients do not have complete normalisation of pressures. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 Outcomes in patients with pulmonary hypertension undergoing percutaneous atrial septal defect closure
肺动脉高压患者行经皮房间隔缺损封堵术的预后
Objectives: To examine the outcomes in patients with moderate or severe pulmonary arterial hypertension (PAH) undergoing percutaneous atrial septal defect (ASD) closure.
目的 ：评估中、重度肺动脉高压(PAH)患者行经皮房间隔缺损封堵术的预后
Design: Retrospective study.
方法：回顾性分析。
Setting: Teaching hospital-based study.
背景：教学医院为研究基础。
Patients: Fifty-four patients with moderate (n = 34) or severe PAH (n = 20) who underwent successful device implantation between 1999 and 2004 were included in the study. Clinical and transthoracic echocardiographic data were reviewed. Pulmonary hypertension was classified as moderate (50–59 mm Hg) or severe (60 mm Hg) according with the right ventricular systolic pressure (RVSP) calculated by echocardiography.
患者：将1999年至2004年间成功接受治疗的54名患有中度肺动脉高压(n = 34)及重度肺动脉高压(n = 20)患者纳入研究范围。回顾性分析临床数据及经胸超声心动图资料，根据超声心动图所测右室舒张压将肺动脉高压分为中度组(50–59 mm Hg)和重度组(60 mm Hg)。
Results: At the early follow-up (mean (SD) 2.3 (1.2) months) all patients were alive and the baseline RVSP decreased from 57 (11) mm Hg to 51 (17) mm Hg (p = 0.003). At the late follow-up (n = 39, mean (SD) duration 31 (15) months) two patients had died and the baseline RVSP decreased from 58 (10) mm Hg to 44 (16) mm Hg (p = 0.004). Although the overall mean RVSP decreased at late follow-up, only 43.6% (17/39) of patients had normalisation (<40 mm Hg) of the RVSP and 15.4% (6/39) had persistent severe PAH.
结果：在随访的早期(平均(SD) 2.3 (1.2) 月)，所有患者均存活，右室舒张压由57（11）mm Hg降至51 （17）mm Hg(p = 0.003)。随访的后期(样本数39,平均持续时间 (SD) 31 (15) 月)，2名患者死亡，右心室舒张压由58 (10) mm Hg 降至44 (16) mm Hg (p = 0.004)。尽管，总体的平均右心室舒张压在随访的后期是降低的，但是仅有43.6% (17/39)的患者右心室舒张压是正常的，而15.4% (6/39)的患者仍然患有严重的肺动脉高压。
Conclusion: Transcatheter closure in patients with secundum ASD and PAH can be successfully performed in selected subjects and is associated with good outcomes. Early improvements in RVSP are seen in patients with moderate or severe PAH undergoing transcatheter ASD closure. Continued improvement in RVSP occurs in late follow-up. Despite decreases in the mean RVSP in late follow-up, many patients do not have complete normalisation of pressures.
结论：经皮房间隔缺损封堵术能够在治疗第二房间隔缺损和肺动脉高压 并且可以取得较好的效果。行经皮房间隔缺损封堵术后，在中重度肺动脉高压患者中早期可以出现右心室舒张压的升高。在随访后期可以出现右心室舒张压的继续升高。尽管在随访后期平均右心室舒张压是降低的，但是多数病人的右心室舒张压并非完全正常 yuanliai 太疏忽了，犯了一个原则性错误。right ventricular systolic pressure (RVSP)，明明是右室收缩压，怎么会是右室舒张压？
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作者:admin@医学,生命科学 2011-03-12 23:50
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