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【科普】哮喘患者气道上皮细胞功能失调
哮喘患者气道上皮细胞功能失调
Published date : 09 Dec 2008
MedWire News: Epithelial cells in the airways of asthmatic children are dysfunctional in their ability to repair wounds, research shows.
Additionally, elevated plasminogen activator inhibitor (PAI)-1 are unable to stimulate epithelial repair in asthmatic cells, report Stephen Stick (Princess Margaret Hospital for Children Perth, Australia) and colleagues in the journal of Clinical and Experimental Allergy.
In patients with asthma, there are structural changes to the airway, including extracellular matrix (ECM) deposition and epithelial damage. Airway epithelial cells (AECs) have been implicated in the remodeling process because they modulate ECM synthesis.
Stick and team note that the plasmin activation system regulates ECM deposition, as well as epithelial cell adhesion, migration, and proliferation. Other studies have shown that PAI-1 expression levels might be involved in the development of airway remodeling associated with asthma.
The researchers isolated AECs from atopic asthmatic and healthy non-atopic children and performed a number of wound repair experiments.
They observed that AECs from the asthmatic children took significantly more time to repair after mechanical wounding than cells from healthy donors.
Additionally, PAI-1 messenger RNA expression was upregulated 68 fold in the isolated asthmatic cells, and the expression and activity of PAI-1 was markedly greater in AECs isolated from asthmatic children compared with healthy controls.
"This elevation appears to be confined to the epithelium because PAI-1 levels in the plasma obtained at the same time as epithelial brushings were not different," comment Stick and colleagues.
PAI-1 expression was significantly elevated following wounding in cells from both cohorts, although total PAI-1 levels were greater in the AECs of the asthmatic children.
Collectively, say the researchers, the data suggest that PAI-1 release is a normal physiologic response to epithelial injury, and this supports the hypothesis that the inability to repair damaged epithelium successfully is responsible for continued elevation of PAI-1 levels in asthma. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Epithelial cells in the airways of asthmatic children are dysfunctional in their ability to repair wounds, research shows.
研究表明，哮喘儿童的呼吸道上皮细胞修复创伤的能力下降。
Additionally, elevated plasminogen activator inhibitor (PAI)-1 are unable to stimulate epithelial repair in asthmatic cells, report Stephen Stick (Princess Margaret Hospital for Children Perth, Australia) and colleagues in the journal of Clinical and Experimental Allergy.
另外，激活的纤溶酶原激活物抑制剂1不能刺激上皮修复哮喘细胞，来自Stephen Stick 和<临床与实验变态反应>杂志的同事报道。
In patients with asthma, there are structural changes to the airway, including extracellular matrix (ECM) deposition and epithelial damage. 哮喘病人的呼吸道的结构发生改变，包括了细胞外基质的沉积和上皮的损伤。
Airway epithelial cells (AECs) have been implicated in the remodeling process because they modulate ECM synthesis.
因为呼吸道上皮细胞调整了细胞基质的合成，所以导致了呼吸道上皮细胞的重构过程的发生。
Stick and team note that the plasmin activation system regulates ECM deposition, as well as epithelial cell adhesion, migration, and proliferation.
Stick 和他的团队注意到纤维蛋白酶激活系统除了拮抗细胞外基质的沉积，还调控上皮细胞的粘附，迁移和增殖。
Other studies have shown that PAI-1 expression levels might be involved in the development of airway remodeling associated with asthma.
其他的研究已经表明纤溶酶原激活物抑制剂-1的表达水平可能与哮喘的呼吸道重构有关。
The researchers isolated AECs from atopic asthmatic and healthy non-atopic children and performed a number of wound repair experiments。
研究人员从患有过敏性哮喘的儿童和健康的没有过敏性哮喘的儿童的呼吸道中分离出各自的呼吸道上皮细胞，并且完成了很多创伤修复实验。
They observed that AECs from the asthmatic children took significantly more time to repair after mechanical wounding than cells from healthy donors.
他们观察到取自哮喘儿童的呼吸道上皮细胞修复机械创伤的时间远远大于健康儿童呼吸道上皮细胞的修复时间。
Additionally, PAI-1 messenger RNA expression was upregulated 68 fold in the isolated asthmatic cells,
另外，分离的哮喘细胞纤溶酶原激活物抑制剂-1信使RNA表达是正常细胞的68倍，
and the expression and activity of PAI-1 was markedly greater in AECs isolated from asthmatic children compared with healthy controls.
在哮喘儿童中呼吸道上皮细胞的纤溶酶原激活物抑制剂-1的表达和活性明显高于正常儿童。
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作者:admin@医学,生命科学 2011-03-12 05:11
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