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Cell：磷脂酶4被证实是心脏疾病的关键因子之一
Contraction of the heart increases in response to sympathetic nervous system activation during the “fight or flight” stress response. This induction is mediated by cAMP-dependent protein kinase (PKA), which activates the ryanodine receptor (RyR2) channel to release more calcium and increase heart muscle contraction. Here, Lehnart et al. show that the phosphodiesterase PDE4D3, which degrades cAMP, is critical to prevent excessive activation of the RyR2 channel. PDE4D3 deficiency in mice causes cardiomyopathy and cardiac arrhythmias due to PKA-hyperphosphorylated, leaky RyR2 channels. These data raise concerns that patients treated with PDE4 inhibitors may be prone to cardiac dysfunction and arrhythmias. 全文连接：
http://www.cell.com/content/article/fulltext?uid=PIIS0092867405007610 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-03-10 17:14
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