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【文摘发布】《Obstetrics and Gynecology》（ 2007年6月
Sherif A. El-Nashar, M***h1, Matthew R. Hopkins, MD1, Simone S. Feitoza, MD1, Rajiv K. Pruthi, MBBS2, Sunni A. Barnes, PhD3, John B. Gebhart, MD, MS1, William A. Cliby, MD1 and Abimbola O. Famuyide, MBBS1
From the 1Department of Obstetrics and Gynecology, the 2Division of Hematology, and the 3Division of Biostatistics, Mayo Clinic, Rochester, Minnesota.
OBJECTIVE: To evaluate the efficacy of global endometrial ablation in women with bleeding disorders who presented with menorrhagia. 目的：评价球囊子宫内膜去除术治疗女性月经失调中月经过多的有效性
内膜球囊电消融治疗月经过多的效果
METHODS: A records-linkage system was used to construct a retrospective cohort of 41 women with bleeding disorders (coagulopathy) and a reference group of 111 randomly selected women without bleeding disorders from a pool of 943 women who underwent global endometrial ablation (with thermal balloon ablation technology or bipolar radiofrequency ablation technology) for menorrhagia at Mayo Clinic (Rochester, Minnesota) from January 1995 through December 2005. Demographic data, type of global endometrial ablation therapy and reablation, and hysterectomy data were extracted from the database. 方法：应用档案连接系统创建一个回顾性研究，41名妇女因血液病导致月经过多（凝血病组），对照组是自1995年2月至2005年12月因月经过多在梅奥门诊部行球囊组宫内膜去除术（包括热球子宫内膜去除术或双极电消融术）的943人中随机选择无月经失调者111人。人口数据、球囊子宫内膜去除术治疗和重新治疗的类型、子宫切除术的数据从数据库中获得。
RESULTS: There was no significant difference in baseline age, parity, body mass index, uterine size, type of global endometrial ablation therapy, or duration of follow-up between the groups. Two women (5%) in the coagulopathy group had hysterectomy or reablation, compared with 8 (7%) in the reference group (Fisher exact test, P=.728). A Kaplan-Meier plot showed no difference in the time to treatment failure between the groups (log-rank test, P=.534). Procedural-related complications were generally minor and infrequent (9 of 152 [6%]). Complications were equally distributed in the coagulopathy (4 of 41) and reference groups (6 of 111) (Fisher exact test, P=.267). 结果：在年龄基线、生育次数、 体表指数、子宫大小、内膜球囊子宫内膜去除术治疗的类型、随访时间方面两组均无显著性差异。在凝血病组中2位（5%）患者进行了子宫切除术或者重新进行了球囊子宫内膜去除术，与对照组中8人（7%）比较用Fisher确切概率法检验，P=0.728. Kaplan-Meier图显示两组治疗失败在时间上没有差异性（log-等级检验，P=0.534)。与手术相关的并发症是很少的，152人中有9人，占6%。并发症在凝血病组的发病率(4 of 41)和对照组(6 of 111)的分布是相当的，(Fisher 精确概率法检验, P=0.267)。
CONCLUSION: Global endometrial ablation is an effective treatment choice for women with coagulopathy presenting with menorrhagia. 结论：球囊子宫内膜去除术对于月经过多的患者来说是一种有效、可选的治疗方法。
球囊子宫内膜去除术治疗女性月经过多的效果
目的：评价球囊子宫内膜去除术治疗女性月经失调中月经过多的有效性
方法：应用档案连接系统创建一个回顾性研究，41名妇女因血液病导致月经过多（凝血病组），对照组是自1995年2月至2005年12月因月经过多在梅奥门诊部行球形子宫内膜去除术（包括热球子宫内膜去除术或双极电消融术）的943人中随机选择无月经失调者111人。人口数据、球囊子宫内膜去除术治疗和重新治疗的类型、子宫切除术的数据从数据库中获得。
结果：在年龄基线、生育次数、 体表指数、子宫大小、内膜球囊子宫内膜去除术治疗的类型、随访时间方面两组均无显著性差异。在凝血病组中2位（5%）患者进行了子宫切除术或者重新进行了球囊子宫内膜去除术，与对照组中8人（7%）比较用Fisher确切概率法检验，P=0.728. Kaplan-Meier图显示两组治疗失败在时间上没有差异性（log-等级检验，P=0.534)。与手术相关的并发症是很少的，152人中有9人，占6%。并发症在凝血病组的发病率(4 of 41)和对照组(6 of 111)的分布是相当的，(Fisher 精确概率法检验, P=0.267)。
结论：球囊子宫内膜去除术对于月经过多的患者来说是一种有效、可选的治疗方法。 Global Endometrial Ablation for Menorrhagia in Women With Bleeding Disorders球囊子宫内膜去除术治疗女性月经过多的效果
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作者:admin@医学,生命科学 2011-02-13 05:11
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