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【medical-news】污染对胎盘的影响
Urban air pollution is associated with poor and adverse pregnancy outcomes, including low birthweight, premature birth, and intrauterine growth retardation. In a paper on p. 578 of the September 2008 issue of Biology of Reproduction, Veras and coworkers present evidence that the effects of urban air pollution on pregnancy outcomes could be related to changes in functional morphology of the placenta. The experiments employed a novel approach in which pregnant female mice were exposed before or during gestation to filtered or nonfiltered air in exposure chambers placed in the garden of the University of Sao Paulo School of Medicine in Brazil. The garden is situated close to a crossroads with high traffic density with about 83,900 cars, 9,900 diesel vehicles, and 6,300 motorcycles circulating daily on the main street of this intersection. Pregnant mice exposed to urban air pollution either before or during gestation produced fetuses of smaller weights compared to those provided filtered air. In addition, the effects of urban air pollution were found to be due to adaptive changes in placental development that ultimately reduce placental function and compromise fetal growth. This is a novel model to dissect the mechanisms of how specific pollutants influence development of the placenta and fetus. These findings are important with respect to the possible transplacental transfer of pollutants from mother to fetus as well as fetal programming and developmental origins of health and disease in adults. Pollution and placenta
污染对胎盘的影响
Urban air pollution is associated with poor and adverse pregnancy outcomes, including low birthweight, premature birth, and intrauterine growth retardation. In a paper on p. 578 of the September 2008 issue of Biology of Reproduction, Veras and coworkers present evidence that the effects of urban air pollution on pregnancy outcomes could be related to changes in functional morphology of the placenta. The experiments employed a novel approach in which pregnant female mice were exposed before or during gestation to filtered or nonfiltered air in exposure chambers placed in the garden of the University of Sao Paulo School of Medicine in Brazil. The garden is situated close to a crossroads with high traffic density with about 83,900 cars, 9,900 diesel vehicles, and 6,300 motorcycles circulating daily on the main street of this intersection. Pregnant mice exposed to urban air pollution either before or during gestation produced fetuses of smaller weights compared to those provided filtered air. In addition, the effects of urban air pollution were found to be due to adaptive changes in placental development that ultimately reduce placental function and compromise fetal growth. This is a novel model to dissect the mechanisms of how specific pollutants influence development of the placenta and fetus. These findings are important with respect to the possible transplacental transfer of pollutants from mother to fetus as well as fetal programming and developmental origins of health and disease in adults.
城市空气污染与不良的妊娠结果有关。其中包括婴儿体重，早产和子宫内发育迟缓。在2008年9月的繁殖生物学上P78页 Veras 和同事展示了城市空气污染对怀孕的影响可能与胎盘的功能形态学的改变有关。进行怀孕老鼠妊娠期巴西Sao Paulo 大学医学院花园中暴露在滤过了和没有滤过空气的一种新的研究方法。花园位于交通稠密的十字交叉路口，主干道上每天评均有 83,900 小车 9,900 柴油机, and 6,300 摩托车。暴露在城市空气污染的妊娠前后的老鼠会导致低体重婴儿。此外，城市空气污染的效应发现是由于胎盘发展的适应性改变，最终导致减少胎盘功能和胎儿死亡。这是一种新的仔细分析具体的污染物是怎样影响胎盘和胎儿的。这些结果关于污染物从母体经胎盘转移至胎儿可能的机制是很重要的，像成人健康和疾病的发展起源和胎儿的形成一样重要。 污染对胎盘的影响
城市空气污染与不良的妊娠结果有关。其中包括婴儿体重，早产和子宫内发育迟缓。在2008年9月的繁殖生物学上P78页 Veras 和同事展示了城市空气污染对怀孕的影响可能与胎盘的功能形态学的改变有关。进行怀孕老鼠妊娠期巴西Sao Paulo 大学医学院花园中暴露在滤过了和没有滤过空气的一种新的研究方法。花园位于交通稠密的十字交叉路口，主干道上每天评均有 83,900 小车 9,900 柴油机, and 6,300 摩托车。暴露在城市空气污染的妊娠前后的老鼠会导致低体重婴儿。此外，城市空气污染的效应发现是由于胎盘发展的适应性改变，最终导致减少胎盘功能和胎儿死亡。这是一种新的仔细分析具体的污染物是怎样影响胎盘和胎儿的。这些结果关于污染物从母体经胎盘转移至胎儿可能的机制是很重要的，像成人健康和疾病的发展起源和胎儿的形成一样重要。 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-01-28 17:14
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