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【medical-news】恶性间皮瘤的免疫组织化学诊断
恶性间皮瘤的免疫组织化学诊断
Objective.—Several new immunohistochemical markers that can assist in the diagnosis of mesotheliomas have been recognized recently. This article reviews the current information available on these markers and also provides a practical approach to the immunohistochemical diagnosis of epithelioid mesotheliomas.
目的：近来发现了几种新的有助于间皮瘤诊断的免疫组化指标。本文综述了关于这些指标现有的使用情况并且提供了上皮性间皮瘤免疫组化诊断的实用性方法。
Data Sources.—Current literature concerning immunohistochemical markers for epithelioid mesotheliomas was collected and reviewed.
资料来源：收集并综述目前关于上皮性间皮瘤免疫组化指标的文献。
Study Selection.—Literature emphasizing immunohistochemical diagnosis of epithelioid mesotheliomas was selected.
研究选择：选择与上皮性间皮瘤免疫组化诊断密切相关的文献。
Data Extraction.—Data deemed helpful to the general surgical pathologist for the diagnosis of epithelioid mesothelioma were included in this review.
资料筛选：把确认为对上皮性间皮瘤常规病理诊断有用的资料引用到本综述中。
Data Synthesis.—Markers identified as potentially useful in the diagnosis of epithelioid mesothelioma include positive markers (namely, calretinin, keratin 5/6, D2-40, podoplanin, mesothelin, and Wilms tumor 1 protein [WT1]) and negative markers (namely, carcinoembryonic antigen, MOC-31, B72.3, and Ber-EP4). Thyroid transcription factor 1 (TTF-1) can assist in determining the lung origin of a
carcinoma, and renal cell carcinoma marker (RCC Ma) may help establish its renal origin.
资料汇总：对上皮性间皮瘤诊断可能有用的阳性指标包括钙视网膜蛋白、角蛋白5/6、D2-40、 podoplanin、间皮素以及肾母细胞瘤蛋白1（WT1）；阴性指标包括癌胚抗原、MOC-31、B72.3以及Ber-EP4。甲状腺转录因子1（TTF-1）能够辅助判断肿瘤是否是肺起源，肾细胞癌标记物（RCC Ma）可以判断是否是肾脏起源。
Conclusions.—D2-40 and podoplanin are the 2 most recently recognized markers that have been found to be useful in the diagnosis of epithelioid mesotheliomas. Since D2-40 and podoplanin appear to be highly sensitive and specific for epithelioid mesotheliomas, either may be considered for inclusion in the battery of antibodies currently recommended for distinguishing epithelioid mesotheliomas from metastatic carcinomas. However, it should be kept in mind that their utility has not yet been fully determined in routine diagnostic work.
结论：D2-40 和 podoplanin是最近发现的两种对诊断上皮性间皮瘤有用的指标。二者对于上皮性间皮瘤有较高的敏感性和特异性，有可能被推荐作为鉴别上皮性间皮瘤和转移性癌的新抗体。然而，必须牢记二者在常规诊断工作中的实用性还未最终确定。
个人见解：D2-40是近几年来发现的特异性很高的淋巴管内皮标记物，且对福尔马林固定石蜡包埋的正常组织和肿瘤组织都有较好的敏感性。目前临床上主要用于标记淋巴管侵犯。近来发现D2-40除对生殖细胞和淋巴管内皮有免疫反应性之外，还对间皮起源的细胞有免疫反应性。已有文献证实D2-40 对上皮性间皮瘤诊断的敏感性与钙视网膜蛋白相当，优于角蛋白5/6和WT1，D2-40很可能成为间皮瘤诊断和鉴别诊断的新的特异性指标。 偶是新手，总是认领不上，只能自己先翻译一篇。其实翻译不是目的，只是给做间皮瘤的通道们一些提示，希望能有帮助。 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-05-25 05:11
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