主页 > 医学讨论 >
【medical-news】儿童治疗爱滋病会增加哮喘风险
"We think this occurs because important immune system components called CD4 cells increase in children treated with highly active antiretroviral therapy," said Dr. William T. Shearer, professor of pediatrics and immunology at BCM in Houston and chief of the allergy and immunology service at Texas Children's Hospital. He is also senior author of the report. CD4 cells are thought to be associated with the inflammation in the lung tissue that accompanies asthma. When CD4 cells decline in children with HIV, their asthma symptoms also decrease.
Shearer and his colleagues evaluated the use of asthma medication among children with HIV who took the anti-HIV drugs and those who did not. They found that about one-third of those on the anti-HIV medications used asthma drugs compared to 11.5 percent of those who did not take anti-HIV drugs.
Shearer said a study that evaluates the lung function of children with HIV on anti-viral therapy would help explain how an increase in the immune system affects the risk of asthma.
"This AIDS model of asthma might help understand at a molecular level what is causing the current epidemic of asthma among children more generally," he said.
Others who took part in the study include Samuel B. Foster and Mary E. Paul of BCM and Texas Children's; Kenneth McIntosh of Harvard Medical School, Bruce Thompson, Ming Lu and Wanrong Yin of Clinical Trials and Surveys Corporation in Baltimore, MD., Kenneth C. Rich of the University of Illinois in Chicago, Hermann Mendez of the State University of New York in Brooklyn, Leslie K. Serchuck of the National Institute of Child Health and Development in Bethesda, MD and Clemente Diaz of the Puerto Rico School of Medicine in San Juan.
Funding for this work came from the National Institutes of Health, the Pediatric Research and Education Fund at Baylor College of Medicine; the David Fund and the Pediatric AIDS Fund and Immunology Research Fund at Texas Children's Hospital.
http://www.mphtimes.com/bbs/viewthread.php?tid=1723&extra=page%3D1&frombbs=1 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 儿童治疗爱滋病会增加哮喘风险
Children whose immune systems rebound after treatment with potent anti-viral drugs for HIV infection face an increased risk of developing asthma, said a federally funded consortium of researchers led by those from Baylor College of Medicine in a new report.
那些用强效抗病毒药物治疗HIV后，免疫系统反弹的儿童面临哮喘增加的危险，一个由Baylor College of Medicine领导的，由联邦政府资助的财团在一份新报告中说。
"We think this occurs because important immune system components called CD4 cells increase in children treated with highly active antiretroviral therapy," said Dr. William T. Shearer, professor of pediatrics and immunology at BCM in Houston and chief of the allergy and immunology service at Texas Children's Hospital. He is also senior author of the report. CD4 cells are thought to be associated with the inflammation in the lung tissue that accompanies asthma. When CD4 cells decline in children with HIV, their asthma symptoms also decrease.
“我们认为，出现这种情况是因为儿童在应用高效抗逆转录病毒疗法后，免疫系统的重要组成部分CD4细胞增加所致。”位于Houston的BMC的儿科和免疫学教授，Texas儿童医院过敏和免疫科主任Dr. William T. Shearer说。他还是这篇报告的主要作者，认为CD4细胞与伴有哮喘的肺部炎症有关。当患有HIV的儿童CD4细胞降低时，哮喘症状也在减少。
Shearer and his colleagues evaluated the use of asthma medication among children with HIV who took the anti-HIV drugs and those who did not. They found that about one-third of those on the anti-HIV medications used asthma drugs compared to 11.5 percent of those who did not take anti-HIV drugs.
Shearer和同事评估了在患有HIV的、服用和未服用抗HIV药物的儿童，哮喘药物的使用情况。他们发现服用抗HIV药物的儿童相比，大约有三分之一服用哮喘药物，而未服用任何抗HIV药物的儿童，只有11.5%服哮喘药物。
Shearer said a study that evaluates the lung function of children with HIV on anti-viral therapy would help explain how an increase in the immune system affects the risk of asthma.
"This AIDS model of asthma might help understand at a molecular level what is causing the current epidemic of asthma among children more generally," he said.
Shearer说一个评价HIV儿童在使用抗HIV治疗时，肺功能的研究可以帮助解释免疫系统的增强是如何影响患哮喘的风险的。他说：“这个AIDS哮喘模型可能有助于在分子水平理解是什么造成了目前哮喘在儿童中更普遍的流行”。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-04-25 17:19
医学,生命科学网