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【medical-news】调节蛋白表达预示乳癌幸存
By David Douglas
NEW YORK (Reuters Health) Dec 15 - Levels of the regulatory protein p27 appear to predict breast cancer survival and relapse in newly diagnosed, moderate-risk patients undergoing adjuvant chemotherapy, researchers report in the December 6th issue of the Journal of the National Cancer Institute.
Lead investigator Dr. Peggy L. Porter told Reuters Health that "our findings indicate that the loss of p27 protein expression is associated with poor survival from breast cancer. This is true for the entire group of over 2,000 women whose tumors were tested, but especially evident in women whose tumors were also hormone receptor positive."
Dr. Porter of the Fred Hutchinson Cancer Research Center, Seattle, and colleagues found that after adjuvant chemotherapy women with newly diagnosed breast cancer and low p27 expression had a hazard ratio of 1.50 for overall survival and 1.31 for disease-free survival. In women with hormone receptor-positive cancer, the corresponding hazard ratios were 1.42 and 1.27
After adjustment for variables such as tumor size and menopausal stage, the influence of p27 levels remained significant. However, there was no significant association between p27 levels and decreased survival in women with hormone-receptor negative tumors.
"It remains to be determined if p27 expression levels could predict response to hormone therapies," Dr. Porter said, "and follow-up studies will address that question."
She added that Dr. James A. Roberts, a co-author of the paper, and other researchers at her institution "are actively evaluating p27 as a potential therapeutic target, and our study lends strong support for the clinical value of that research."
J Natl Cancer Inst 2006;98:1723-1731.
Regulatory Protein Expression Tied to Breast Cancer Survival
调节蛋白表达预示乳癌幸存
By David Douglas
NEW YORK (Reuters Health) Dec 15 - Levels of the regulatory protein p27 appear to predict breast cancer survival and relapse in newly diagnosed, moderate-risk patients undergoing adjuvant chemotherapy, researchers report in the December 6th issue of the Journal of the National Cancer Institute.
纽约（路透社健康版）12月15日—调节蛋白p27的水平似乎预示着近期诊断的正在接受辅助化疗的中度危险患者乳癌幸存和复发，研究人员报告在12月第6期国家肿瘤协会杂志上。
Lead investigator Dr. Peggy L. Porter told Reuters Health that "our findings indicate that the loss of p27 protein expression is associated with poor survival from breast cancer. This is true for the entire group of over 2,000 women whose tumors were tested, but especially evident in women whose tumors were also hormone receptor positive."
首席调查人Peggy L. Porter博士告诉路透社健康版“我们的发现显示p27蛋白表达的降低与乳癌的低幸存相关。这来源于2000名接受测试的肿瘤妇女的团体，结果是真实的，尤其明显的是那些肿瘤为激素受体阳性的。”
Dr. Porter of the Fred Hutchinson Cancer Research Center, Seattle, and colleagues found that after adjuvant chemotherapy women with newly diagnosed breast cancer and low p27 expression had a hazard ratio of 1.50 for overall survival and 1.31 for disease-free survival. In women with hormone receptor-positive cancer, the corresponding hazard ratios were 1.42 and 1.27
来自西雅图Fred Hutchinson肿瘤研究中心的 Porter博士和同事们发现新近诊断和低p27 表达的乳癌的妇女辅助化疗后的危险系数是整体生存1.50和无疾病生存1.31。在激素受体阳性肿瘤妇女，对应的危险系数是1.42 和1.27。
After adjustment for variables such as tumor size and menopausal stage, the influence of p27 levels remained significant. However, there was no significant association between p27 levels and decreased survival in women with hormone-receptor negative tumors.
调整可变量譬如肿瘤大小和绝经期后，p27 水平的影响依然是重大。但是, 在肿瘤激素受体阴性的妇女中p27 水平和生存减少之间并没有有意义的关联。
"It remains to be determined if p27 expression levels could predict response to hormone therapies," Dr. Porter said, "and follow-up studies will address that question."
"余下的工作就是确定是否p27 表示水平能预示对激素疗法的反应, " Porter 博士说, "并且追踪的研究将揭示这些问题。"
She added that Dr. James A. Roberts, a co-author of the paper, and other researchers at her institution "are actively evaluating p27 as a potential therapeutic target, and our study lends strong support for the clinical value of that research."
她补充说, 本文的合著者James A. Roberts博士和在她的机构的其它研究员们"积极地评估了作为一个潜在的治疗目标的p27, 并且我们的研究给那项研究的临床价值带来强烈支持." 试着提点建议，共同进步
1、in the December 6th issue of the Journal of the National Cancer Institute
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作者:admin@医学,生命科学 2011-04-02 05:11
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