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进展编译—Science:内皮细胞刺激神经干细胞自我

题目:内皮细胞刺激神经干细胞的自我更新和扩增

摘要:神经干细胞被认为存在于血管龛(vascular niche),但是没有直接的证据显示干细胞与血管成分细胞之间有功能性的联系。我们观察到,内皮细胞(不是血管平滑肌细胞)释放可溶性的因子刺激神经干细胞的自我更新,抑制它们的分化,提高它们神经元的产量。胚胎和成年神经干细胞都有此反应,在体外培养条件下可以产生大量的投射神经元和中间神经元。内皮的共培养刺激神经上皮细胞联系,激活Notch和Hes1促进自我更新。这些发现证明内皮细胞是神经干细胞龛的主要成分。

Science, Vol 304, Issue 5675, 1338-1340, 28 May 2004

Endothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem Cells

Neural stem cells are reported to lie in a vascular niche, but there is no direct evidence for a functional relationship between the stem cells and blood vessel component cells. We show that endothelial cells but not vascular smooth muscle cells release soluble factors that stimulate the self-renewal of neural stem cells, inhibit their differentiation, and enhance their neuron production. Both embryonic and adult neural stem cells respond, allowing extensive production of both projection neuron and interneuron types in vitro. Endothelial coculture stimulates neuroepithelial cell contact, activating Notch and Hes 1 to promote self-renewal. These findings identify endothelial cells as a critical component of the neural stem cell niche.

全文链接:http://www.sciencemag.org/cgi/reprint/304/5675/1338.pdf [标签:content1][标签:content2]

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作者:admin@医学,生命科学    2011-03-31 17:14
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