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【medical-news】激素替代治疗不能延缓痴呆的发生
NEW YORK (Reuters Health) - The long-term use of estrogen or estrogen plus progestin hormone therapy does not reduce the risk of dementia, according to findings published in the American Journal of Epidemiology.
"Results from (previous) studies of the relation between hormone therapy and Alzheimer's disease conflict," Dr. Valerie Crooks, of Kaiser Permanente Southern California, Pasadena, and colleagues write.
The researchers report the results of a forward-looking study of about 2,900 women, at least 75 years of age, who were recruited from a Southern California health plan in 1999. The subjects, who were free from dementia when the study began, were followed through 2003 with tests performed annually to assess their thinking ability.
Just over 1500 of the women in the study were hormone users. The average age at the start of hormone therapy was 48.3 years for those who used estrogen alone and 54.9 years for those who used estrogen/progestin. The average duration of hormone use was 30.5 years and 23.2 years for estrogen and estrogen/progestin users, respectively.
A total of 283 women developed dementia during follow-up. After accounting for age, education, and self-reported medical history, hormone use did not affect the risk of dementia.
"This study also determined that no protective effect against dementia was found for women who initiated hormone therapy at or near menopause," Crooks told Reuters Health.
"How hormone therapy can affect dementia risk is not fully understood," she said. "This study, however, adds to the evidence that hormone use does not prevent the development of dementia in older women." 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 Hormone therapy does not prevent dementia
激素替代疗法不能延缓痴呆发生
NEW YORK (Reuters Health) - The long-term use of estrogen or estrogen plus progestin hormone therapy does not reduce the risk of dementia, according to findings published in the American Journal of Epidemiology.
纽约路透社健康报道--美国流行病学杂志刊登的研究结果表明，长期使用激素替代治疗----使用雌激素或是雌激素与孕激素联用，不能降低罹患痴呆的风险。
"Results from (previous) studies of the relation between hormone therapy and Alzheimer's disease conflict," Dr. Valerie Crooks, of Kaiser Permanente Southern California, Pasadena, and colleagues write.
此前关于激素替代疗法对老年痴呆症的影响的研究存在分歧，南加州凯萨医疗中心的Valerie Crooks博士说。
The researchers report the results of a forward-looking study of about 2,900 women, at least 75 years of age, who were recruited from a Southern California health plan in 1999. The subjects, who were free from dementia when the study began, were followed through 2003 with tests performed annually to assess their thinking ability.
研究者报道了对2900名妇女的前瞻性研究结果，这些妇女的平均年龄为75岁，她们1999年参加了南加州健康计划。作为研究对象，这些在研究之始没有痴呆症的妇女在99年到2003年期间每年接受关于思维水平的测试。
Just over 1500 of the women in the study were hormone users. The average age at the start of hormone therapy was 48.3 years for those who used estrogen alone and 54.9 years for those who used estrogen/progestin. The average duration of hormone use was 30.5 years and 23.2 years for estrogen and estrogen/progestin users, respectively.
研究对象中有1500余人接受过激素治疗。单独使用雌激素的妇女，开始使用激素的平均年龄是48.3岁，雌激素和孕激素联合使用的妇女，开始使用激素时平均年龄是54.9岁。前者和后者使用激素治疗的平均使用期分别为30.5年和23.2年。
A total of 283 women developed dementia during follow-up. After accounting for age, education, and self-reported medical history, hormone use did not affect the risk of dementia.
在随后的跟踪研究中有283名妇女患有老年痴呆。对痴呆与年龄，教育程度和自诉的用药史的研究表明，使用激素对老年痴呆的发生没有影响。
"This study also determined that no protective effect against dementia was found for women who initiated hormone therapy at or near menopause," Crooks told Reuters Health.
Crooks 说道，这项研究也同时可以说明，妇女在绝经或接近绝经期时开始接受激素替代疗法，对痴呆的发生没有预防作用。
"How hormone therapy can affect dementia risk is not fully understood," she said. "This study, however, adds to the evidence that hormone use does not prevent the development of dementia in older women."
激素疗法对痴呆发生的影响研究尚不充分，她说，但这项研究提供了部分证据，那就是激素使用对老年妇女痴呆的发生没有延缓作用。
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作者:admin@医学,生命科学 2011-01-22 17:14
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