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【J Clin Oncol】乳腺癌后淋巴水肿的发生率，危险
Purpose: Secondary lymphedema is associated with adverse physical and psychosocial consequences among women with breast cancer (BC). This article describes the prevalence and incidence of lymphedema between 6 and 18 months after BC treatment; personal, treatment, and behavioral correlates of lymphedema status; and the presence of other upper-body symptoms (UBS) and function (UBF).
Patients and Methods: A population-based sample of Australian women (n = 287) with recently diagnosed, invasive BC were evaluated on five occasions using bioimpedance spectroscopy. Lymphedema was diagnosed when the ratio of impedance values, comparing treated and untreated sides, was three standard deviations more than normative data. UBF was assessed using the validated Disability of the Arm, Shoulder, and Hand questionnaire.
Results: From 6 to 18 months after surgery, 33% (n = 62) of the sample were classified as having lymphedema; of these, 40% had long-term lymphedema. Although older age, more extensive surgery or axillary node dissection, and experiencing one or more treatment-related complication( s ) or symptom( s ) at baseline were associated with increased odds, lower socioeconomic status, having a partner, greater child care responsibilities, being treated on the dominant side, participation in regular activity, and having good UBF were associated with decreased odds of lymphedema. Not surprisingly, lymphedema leads to reduced UBF; however, BC survivors report high prevalences of other UBS (34% to 62%), irrespective of their lymphedema status.
Conclusion: Lymphedema is a public health issue deserving greater attention. More systematic surveillance for earlier detection and the potential benefits of physical activity to prevent lymphedema and mitigate symptoms warrant further clinical integration and research.
http://jco.ascopubs.org/cgi/content/abstract/26/21/3536 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Lymphedema After Breast Cancer: Incidence, Risk Factors, and Effect on Upper Body Function
乳腺癌后淋巴水肿的发生率，危险因素和对上身功能的影响
Purpose: Secondary lymphedema is associated with adverse physical and psychosocial consequences among women with breast cancer (BC). This article describes the prevalence and incidence of lymphedema between 6 and 18 months after BC treatment; personal, treatment, and behavioral correlates of lymphedema status; and the presence of other upper-body symptoms (UBS) and function (UBF).
目的：在乳腺癌患者女性中，继发性淋巴水肿可造成身体和社会心理方面的负面影响。这个研究阐述了乳腺癌治疗6到18个月后，淋巴水肿的发生率；个性，治疗，和行为与淋巴水肿状态的关系；并描写了出现的其他上身的症状和功能异常
Patients and Methods: A population-based sample of Australian women (n = 287) with recently diagnosed, invasive BC were evaluated on five occasions using bioimpedance spectroscopy. Lymphedema was diagnosed when the ratio of impedance values, comparing treated and untreated sides, was three standard deviations more than normative data. UBF was assessed using the validated Disability of the Arm, Shoulder, and Hand questionnaire.
病人和方法：对澳大利亚新诊断为进展期乳腺癌的一项人群研究，生物电阻抗频谱分析法(bio-impedance spectroscopy）和5个时间。 淋巴水肿的诊断：电阻抗值的比例，比较治疗一侧与未治疗侧，如与正常数据有超过三个标准差（standard deviations）。 上身功能的评估：用经证实的的手臂，肩和手残疾的问卷。
Results: From 6 to 18 months after surgery, 33% (n = 62) of the sample were classified as having lymphedema; of these, 40% had long-term lymphedema. Although older age, more extensive surgery or axillary node dissection, and experiencing one or more treatment-related complication( s ) or symptom( s ) at baseline were associated with increased odds, lower socioeconomic status, having a partner, greater child care responsibilities, being treated on the dominant side, participation in regular activity, and having good UBF were associated with decreased odds of lymphedema. Not surprisingly, lymphedema leads to reduced UBF; however, BC survivors report high prevalences of other UBS (34% to 62%), irrespective of their lymphedema status.
结果：在手术后的6到18个月，33%(n = 62)的患者有淋巴水肿，其中，40%淋巴水肿长期存在。虽然高龄，更广泛的手术或腋窝淋巴结清扫，具有一个或以上的治疗相关并发症或症状与淋巴水肿发病增加相关。 较低的社会经济地位，有伴侣，有较重的照顾小孩的责任，在优势的一侧接受治疗，经常参加日常活动，有很好的上肢功能与淋巴水肿下降相关。并不奇怪，淋巴水肿能影响上身功能；然而，乳腺癌幸存者报告了其他的上身异常症状(34% 到 62%), 而与她们的淋巴水肿状态无关。
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作者:admin@医学,生命科学 2010-09-28 05:11
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