主页 > 医学讨论 >
【medical-news】研究首次证明某些HIV亚型增加痴呆
http://www.sciencedaily.com/releases/2009/08/090828164528.htm
ScienceDaily (Aug. 29, 2009) — Patients infected with a particular subtype of HIV, the virus that causes AIDS, are more likely to develop dementia than patients with other subtypes, a study led by Johns Hopkins researchers shows. The finding, reported in the September Clinical Infectious Diseases, is the first to demonstrate that the specific type of HIV has any effect on cognitive impairment, one of the most common complications of uncontrolled HIV infection.
HIV occurs in multiple forms, distinguished by small differences in the virus' genetic sequence and designated by letters A through K. Certain subtypes appear to cluster in particular areas of the world, and others have been associated with different rates of progression to full blown AIDS. Of the 35 million people living worldwide with HIV, the majority live in sub-Saharan Africa, where subtypes A, C and D dominate.
Nearly half of patients with advanced HIV infections have at least mild cognitive impairments, and about 5 percent have the severe form of cognitive impairment known as dementia.
In earlier research, Ned Sacktor, M.D., and his colleagues found that about 31 percent of patients visiting an infectious disease clinic in the Ugandan capital, Kampala, where subtypes A and D dominate, had dementia. The finding led him and his team to wonder whether patients with different subtypes had different rates of dementia.
Sacktor, professor of neurology at the Johns Hopkins University School of Medicine and a clinician at the Johns Hopkins Bayview Medical Center, and his colleagues studied 60 HIV-infected patients from a Kampala clinic. All of the subjects had been part of a different study testing the effect of anti-retroviral drugs on cognitive impairment, but had not begun taking the drugs. After determining each patient's HIV subtype, they performed a battery of neurological and cognitive tests to assess each patient's brain function.
As expected, the majority of the patients had HIV subtypes A or D. Out of the 33 subtype A patients, the researchers determined that seven had dementia, or about 24 percent. However, out of the nine patients with subtype D, 8 had dementia, about 89 percent.
"We were amazed to see such a dramatic difference in dementia frequencies between these two subtypes," Sacktor says. "If this is the case in all of sub-Saharan Africa, HIV-associated dementia may be one of the most common, but thus far unrecognized, dementias worldwide."
The research suggests that some biological property of each subtype seems to influence the likelihood that infected patients will develop dementia, says Sacktor. He and his team hypothesize that subtype D may cause more inflammation and injury in the brain, a possibility they are currently investigating. HIV Subtype Linked To Increased Likelihood For Dementia
HIV亚型增加痴呆风险
ScienceDaily (Aug. 29, 2009) — Patients infected with a particular subtype of HIV, the virus that causes AIDS, are more likely to develop dementia than patients with other subtypes, a study led by Johns Hopkins researchers shows. The finding, reported in the September Clinical Infectious Diseases, is the first to demonstrate that the specific type of HIV has any effect on cognitive impairment, one of the most common complications of uncontrolled HIV infection.
ScienceDaily（2009年8月29日） ----特定HIV亚型感染的艾滋病人，比其他亚型的病人更有可能发展痴呆症，由约翰霍普金斯大学的一项研究显示，研究结果刊登在9月份的临床传染病杂志，这是第一次证明艾滋病毒的某种特定的亚型对认知障碍有影响，认知障碍是HIV感染最常见的并发症之一。
HIV occurs in multiple forms, distinguished by small differences in the virus' genetic sequence and designated by letters A through K. Certain subtypes appear to cluster in particular areas of the world, and others have been associated with different rates of progression to full blown AIDS. Of the 35 million people living worldwide with HIV, the majority live in sub-Saharan Africa, where subtypes A, C and D dominate.
艾滋病毒有多种亚型（以字母命名，包括由A到K的11个亚型），区别在于病毒基因序列的微小差异，某些亚型在一定的地理区域较为集中，其他的亚型则与艾滋病的进展速度不同有关。 全球3500万艾滋病毒感染者中，大多数人生活在撒哈拉以南中部非洲地区，其中大部分属于亚型A、C和D。
Nearly half of patients with advanced HIV infections have at least mild cognitive impairments, and about 5 percent have the severe form of cognitive impairment known as dementia.
近半的晚期艾滋病患者有轻度以上的认知损伤，有5%的患者有重度认知障碍。
In earlier research, Ned Sacktor, M.D., and his colleagues found that about 31 percent of patients visiting an infectious disease clinic in the Ugandan capital, Kampala, where subtypes A and D dominate, had dementia. The finding led him and his team to wonder whether patients with different subtypes had different rates of dementia.
阅读本文的人还阅读：
作者:admin@医学,生命科学 2010-10-02 19:08
医学,生命科学网