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【drug-news】研究表明阿司匹林可能预防哮喘
Aspirin may prevent asthma in adults: study
Mon Jan 15, 2007 9:51 PM GMT
NEW YORK (Reuters Health) - Results from the Physicians Health Study indicate that regular use of aspirin may reduce the risk of "new-onset" asthma in adults by 22 percent.
However, there is no evidence that aspirin improves symptoms in people who already have asthma, and it may, of course, cause acute breathing difficulties among individuals with "aspirin-intolerant asthma."
Dr. Tobias Kurth, at Brigham and Women's Hospital in Boston, and associates examined data from the Physicians' Health Study, which at one point involved more than 22,000 men randomized to aspirin or placebo.
The healthy subjects, aged 40 to 84 years and free of asthma at baseline in 1982, were randomly assigned to a single 325-mg tablet of aspirin or placebo on alternate days. This aspect of the study was terminated after an average of 4.9 years because of the reduction in risk of a first heart attack associated with aspirin use.
The risk of newly diagnosed asthma was reduced by 22 percent in the aspirin arm of the study, as mentioned.
The investigators' stratified analysis showed that the reduction in new diagnoses of asthma was greater among those who had never smoked and among those who were older than 45.9 years at baseline.
Kurth and his associates point out that aspirin-intolerant asthma affects 4 percent to 11 percent of asthma patients, particularly adults, who may respond to an aspirin challenge with severe bronchospasm (tightness in the chest).
So, while the researchers propose that aspirin may decrease the onset of asthma in adults, they absolutely "do not imply that aspirin improves symptoms in patients with asthma."
SOURCE: American Journal of Respiratory and Critical Care Medicine January 2007. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Aspirin may prevent asthma in adults: study
Mon Jan 15, 2007 9:51 PM GMT
研究表明阿司匹林可能预防哮喘
NEW YORK (Reuters Health) - Results from the Physicians Health Study indicate that regular use of aspirin may reduce the risk of "new-onset" asthma in adults by 22 percent.
纽约（路透社健康）报道，来自医生健康研究的结果表明，规律服用阿司匹林可使成人“新发”哮喘的风险降低22%。
However, there is no evidence that aspirin improves symptoms in people who already have asthma, and it may, of course, cause acute breathing difficulties among individuals with "aspirin-intolerant asthma."
不过，目前尚无资料证实阿司匹林可改善已有哮喘者的症状。另外，对于那些有阿司匹林性哮喘的患者，阿司匹林还可导致急性呼吸困难。
Dr. Tobias Kurth, at Brigham and Women's Hospital in Boston, and associates examined data from the Physicians' Health Study, which at one point involved more than 22,000 men randomized to aspirin or placebo.
来自波士顿百翰和妇女医院的Tobias Kurth博士及其同事对医生健康研究的数据进行了分析。医生健康研究一次性地纳入了超过22，000名的男性受试者，他们被随机分配服用阿司匹林或安慰剂。
The healthy subjects, aged 40 to 84 years and free of asthma at baseline in 1982, were randomly assigned to a single 325-mg tablet of aspirin or placebo on alternate days. This aspect of the study was terminated after an average of 4.9 years because of the reduction in risk of a first heart attack associated with aspirin use.
基线1982年时，所有受试者年龄为40~84岁，健康、无哮喘，随机接受隔日一次的单片剂量为325 mg的阿司匹林或安慰剂。因阿司匹林降低了受试者的首次心脏病风险，研究于平均4.9年后终止。
The risk of newly diagnosed asthma was reduced by 22 percent in the aspirin arm of the study, as mentioned.
研究者提到，新发哮喘风险降低了22%。
The investigators' stratified analysis showed that the reduction in new diagnoses of asthma was greater among those who had never smoked and among those who were older than 45.9 years at baseline.
分层分析表明，从不吸烟以及基线时年龄大于45.9岁的受试者新发哮喘风险降低更为明显。
Kurth and his associates point out that aspirin-intolerant asthma affects 4 percent to 11 percent of asthma patients, particularly adults, who may respond to an aspirin challenge with severe bronchospasm (tightness in the chest).
Kurth博士及其同事指出，阿司匹林耐受哮喘影响4%~11%的哮喘患者，尤其是成人患者，这些人服用阿司匹林后可能的反应是支气管痉挛（胸部紧缩感）。
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作者:admin@医学,生命科学 2011-04-17 05:11
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