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【科普】早期抗生素使用不会增加继后患哮喘或
早期抗生素使用不会增加继后患哮喘或过敏风险
Published date : 05 Dec 2008
MedWire News: The use of antibiotics in the first year of life does not increase the risk for developing asthma or atopic diseases later in childhood, research shows.
"Although we found children who had antibiotics in the first year of life had more than twice the odds of a doctor diagnosis of asthma, this relationship was reduced after adjustment," comment Merci Kusel (University of Western Australia, Subiaco) and colleagues in the journal Clinical and Experimental Allergy.
The increasing prevalence of atopic diseases, primarily in developed countries, has led some to speculate that reduced postnatal microbial stimulation resulting from improved public health measures, smaller families, and increased antibiotic use might be the cause of the rise of atopic illnesses.
In this investigation, the researchers identified 198 children genetically predisposed to atopy and monitored them for 5 years. Illnesses and antibiotic use were obtained with daily diaries and diagnoses of asthma and other atopic diseases were collected by questionnaire.
Results showed that 54% of children received at least one course of antibiotics, mainly for acute respiratory illnesses.
Antibiotic use was associated with a significantly greater risk for developing asthma (odds ratio=2.3), but the association was no longer significant after propensity score adjustment. There were no observed associations between antibiotic use and eczema, current wheeze, current asthma, atopic asthma, allergic rhinoconjunctivitis, or atopy.
The researchers note that observational studies showing causal links between asthma and early antibiotic use are confounded by the now discouraged use of antibiotics for wheezing illnesses in early childhood.
“Care must therefore be taken in the interpretation of these studies because of issues of confounding, as it is plausible that children with asthma are more likely to present with wheezing illnesses early in life and are thus more likely to be prescribed antibiotics,” Kusel et al write.
“Causal links could, however, be strengthened if an association is found between antibiotic use for non-asthma-related conditions and atopic disease.” Early antibiotic use does not lead to later asthma or atopy
早期抗生素使用不会导致日后的哮喘和过敏
Published date : 05 Dec 2008
发布时间：2008年12月5日
MedWire News: The use of antibiotics in the first year of life does not increase the risk for developing asthma or atopic diseases later in childhood, research shows.
医学在线新闻：研究发现，在生命的第一年使用抗生素并不增加日后童年哮喘或过敏性疾病的风险。
"Although we found children who had antibiotics in the first year of life had more than twice the odds of a doctor diagnosis of asthma, this relationship was reduced after adjustment," comment Merci Kusel (University of Western Australia, Subiaco) and colleagues in the journal Clinical and Experimental Allergy.
“尽管我们发现儿童在一岁以内使用抗生素两次以上，医生诊断哮喘的几率增加，调整后，两者的联系减少。”米歇尔（撒博卡，西澳大利亚大学）和他的同事在临床变态反应杂志上评论到。
The increasing prevalence of atopic diseases, primarily in developed countries, has led some to speculate that reduced postnatal microbial stimulation resulting from improved public health measures, smaller families, and increased antibiotic use might be the cause of the rise of atopic illnesses.
变应性疾病流行的增加最初发生在发达国家，从而引起一些推测：因公众卫生措施导致微生物刺激减少、较小的家庭、使用抗生素增加或许导致过敏性疾病的风险。
In this investigation, the researchers identified 198 children genetically predisposed to atopy and monitored them for 5 years. Illnesses and antibiotic use were obtained with daily diaries and diagnoses of asthma and other atopic diseases were collected by questionnaire.
在这项调查中，研究者鉴定了198例有遗传性过敏症的儿童，并随访5年。疾病和抗生素的使用被记录在每日的日记上，哮喘和其他过敏性疾病的诊断通过调查问卷收集。
Results showed that 54% of children received at least one course of antibiotics, mainly for acute respiratory illnesses.
结果显示54%的儿童大多数因为急性呼吸道疾病，接受了至少一个疗程的抗生素。
Antibiotic use was associated with a significantly greater risk for developing asthma (odds ratio=2.3), but the association was no longer significant after propensity score adjustment. There were no observed associations between antibiotic use and eczema, current wheeze, current asthma, atopic asthma, allergic rhinoconjunctivitis, or atopy.
抗生素的使用和有意义的哮喘风险的增加有关（让步比=2.3），但是其间的联系在习性评分调整后无显著差异。在抗生素使用和湿疹、流行性哮喘、气喘、变应性哮喘、过敏性鼻炎结膜炎或遗传性过敏症之间并没有明确的联系。
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作者:admin@医学,生命科学 2011-04-16 17:11
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