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【medical-news】细菌感染治疗的妙招：骗术
Freeloading microbes could help their hosts by undermining cooperation between pathogens.
Asher Mullard
Infections could be treated by adding more bacteria, say researchers who have shown that cooperation between microbes is undermined outside the bounds of the Petri dish by a few 'cheats'.
Similar to colonies of social creatures such as ants, bacteria can rely on a simple solution to the difficulties of surviving in harsh environments — cooperation. Populations of bacteria can communicate with one another to coordinate their feeding and swarming activity, and sometimes even sacrifice themselves for the greater good. Although cooperators pay a cost, for instance in producing the molecules that enable communication, they thrive because they are stronger as a society than as individuals.
Speaking at a meeting hosted by the Royal Society in London, evolutionary biologist Stuart West from the University of Edinburgh, UK, has shown that cooperative behaviour can fall apart in animal infections because of an insidious, but inevitable, element in all societies — cheats.
Such freeloaders can quickly outnumber the cooperators by taking advantage of the hard work of these bacterial good samaritans, causing the cooperative society to crumble — thereby making infections less virulent, he explains. These findings, which suggest that infections could be treated by undermining bacterial social structures with subversive cheaters, are in press with the journal Current Biology.
Communication breakdown
Bacterial cooperation often involves a form of communication called quorum sensing. Bacteria release a quorum-sensing molecule that others can detect and use to coordinate their behaviour. Sneakily, some bacteria don't produce these molecules but can still detect their presence and gain the benefits of cooperation without paying any of the costs. Previous work1 has shown that these cheaters consequently thrive, outnumbering the cooperators and undermining the social order. However, this conflict had previously only been shown in test tubes and Petri dishes, says West.
Now, West and his colleagues have infected mice with the disease-causing bacterium Pseudomonas aeruginosa to see if this conflict occurs in a more natural environment. They found that mice infected with cooperating, signal-producing bacteria died within a few days, but those that were infected with bacterial freeloaders had much lower mortality. Mice that were treated with a mixture of cooperators and cheaters, however, had the same high survival rates as those that had been infected with cheaters only.
Evolutionary conflict between these groups of bacteria stops "the harmful toxin-producing virulence of wild-type bacteria", says West. "We could theoretically decrease the virulence of some infections just by adding cheating bacteria into the host."
This approach could be even more powerful if the cheating microbes were engineered to be susceptible to antibiotics.
Natural accuracy
"It would be great if something came out of this," says evolutionary biologist David Queller from Rice University in Houston, Texas, who was also at the meeting. But Queller has his concerns: "The first thing that I think about is 'do you really want to add bacteria to a [sick patient]?'"
For researchers who want to understand the evolutionary history of the genes that drive cooperative behaviour, bacteria offer both promise and problems, says Queller. Bacteria can be grown easily in controlled conditions, allowing scientists to study the effects of just one gene, for example. But looking at them in their natural living conditions is difficult, he says.
"I think it's an important step to try to look at what these things are doing in their natural environment — in this case in mice," adds Queller.
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References
1. Diggle, S. P., Griffin, A. S., Campbell, G. S. & West, S. A. Nature 450, 411– 414 (2007).
http://www.nature.com/news/2009/090121/full/news.2009.47.html 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Cheating bacteria could treat infections
细菌感染治疗的妙招：骗术
Freeloading microbes could help their hosts by undermining cooperation between pathogens.
不劳而获的细菌通过破坏致病菌之间的合作可以帮助宿主。
Asher Mullard
作者：Asher Mullard
Infections could be treated by adding more bacteria, say researchers who have shown that cooperation between microbes is undermined outside the bounds of the Petri dish by a few 'cheats'.
研究人员说，治疗感染可以通过加入更多的细菌来做到，并指出，他们在皮氏培养皿外用骗术破坏了微生物间的合作。
Similar to colonies of social creatures such as ants, bacteria can rely on a simple solution to the difficulties of surviving in harsh environments — cooperation. Populations of bacteria can communicate with one another to coordinate their feeding and swarming activity, and sometimes even sacrifice themselves for the greater good. Although cooperators pay a cost, for instance in producing the molecules that enable communication, they thrive because they are stronger as a society than as individuals.
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作者:admin@医学,生命科学 2011-04-07 17:18
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