主页 > 医学前沿 >
【文摘发布】神经干细胞注射入噪声损伤耳蜗后
Parker MA, Corliss DA, Gray B。
Hear Res. 2007 Oct;232(1-2):29-43.
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17659854&ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Most cases of hearing loss are caused by the death or dysfunction of one of the many cochlear cell types. We examined whether cells from a neural stem cell line could replace cochlear cell types lost after exposure to intense noise. For this purpose, we transplanted a clonal stem cell line into the scala tympani of sound damaged mice and guinea pigs. Utilizing morphological, protein expression and genetic criteria, stem cells were found with characteristics of both neural tissues (satellite, spiral ganglion, and Schwann cells) and cells of the organ of Corti (hair cells, supporting cells). Additionally, noise-exposed, stem cell-injected animals exhibited a small but significant increase in the number of satellite cells and Type I spiral ganglion neurons compared to non-injected noise-exposed animals. These results indicate that cells of this neural stem cell line migrate from the scala tympani to Rosenthal's canal and the organ of Corti. Moreover, they suggest that cells of this neural stem cell line may derive some information needed from the microenvironment of the cochlea to differentiate into replacement cells in the cochlea. Neural stem cells injected into the sound-damaged cochlea migrate throughout the cochlea and express markers of hair cells, supporting cells, and spiral ganglion cells.
神经干细胞注射入噪声损伤耳蜗后遍及整个耳蜗并表达毛细胞、支持细胞及螺旋神经节细胞的标记物
Parker MA, Corliss DA, Gray B。
Hearing Resarch. 2007 Oct;232(1-2):29-43.
Most cases of hearing loss are caused by the death or dysfunction of one of the many cochlear cell types.
引起听力下降的大多数原因是由于耳蜗内多种细胞的其中一种的死亡或者功能障碍所引起的。
We examined whether cells from a neural stem cell line could replace cochlear cell types lost after exposure to intense noise.
我们观察了神经干细胞系细胞是否可以替代耳蜗内强噪声暴露后所致的细胞缺失。
For this purpose, we transplanted a clonal stem cell line into the scala tympani of sound damaged mice and guinea pigs. Utilizing morphological, protein expression and genetic criteria, stem cells were found with characteristics of both neural tissues (satellite, spiral ganglion, and Schwann cells) and cells of the organ of Corti (hair cells, supporting cells).
出于这一目的，我们将克隆的干细胞系移植入噪声损伤后的小鼠和豚鼠的鼓阶内。通过采用形态学、蛋白表达及基因表达的标准，我们发现干细胞具有神经组织（卫星细胞、螺旋神经节及Schwann细胞）和Corti氏器细胞（毛细胞和支持细胞）这两者的特征。
Additionally, noise-exposed, stem cell-injected animals exhibited a small but significant increase in the number of satellite cells and Type I spiral ganglion neurons compared to non-injected noise-exposed animals.
此外，噪声暴露，干细胞注射动物与没有注射动物相比表现出小的但是显著的卫星细胞和I型螺旋神经节神经元细胞数目的增加。
These results indicate that cells of this neural stem cell line migrate from the scala tympani to Rosenthal's canal and the organ of Corti. Moreover, they suggest that cells of this neural stem cell line may derive some information needed from the microenvironment of the cochlea to differentiate into replacement cells in the cochlea.
这一结果提示，神经干细胞系的细胞自鼓阶迁移至Rosenthal隧道和Corti氏器。而且，结果还提示，这些神经干细胞系细胞可能从耳蜗内的微环境中获得了必须的信息以分化成耳蜗内被替换的细胞。 编译
神经干细胞移植入噪声损伤耳蜗后迁移至整个耳蜗并表达毛细胞、支持细胞及螺旋神经节细胞的标记物
Parker MA, Corliss DA, Gray B。
Hearing Resarch. 2007 Oct;232(1-2):29-43.
引起听力下降的大多数原因是由于耳蜗内多种细胞的其中一种的死亡或者功能障碍所引起的。我们观察了神经干细胞系细胞移植入耳蜗后是否可以替代强噪声损伤后所引起的细胞缺失。
出于这一目的，我们将克隆的干细胞系移植入噪声损伤后的小鼠和豚鼠的鼓阶内。采用形态学、蛋白表达及基因表达的标准，我们发现干细胞同时具有了神经组织（卫星细胞、螺旋神经节细胞及Schwann细胞）和Corti氏器细胞（毛细胞和支持细胞）这两者的特征。此外，噪声暴露后干细胞移植后动物与没有移植动物相比，表现出小的但是显著的卫星细胞和I型螺旋神经节神经元细胞数目的增加。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-04-06 17:11
医学,生命科学网