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【medical-news】顽固性抑郁症治疗新希望
MUSC Research Offers Hope For Those Resistant To Depression Treatment
Article Date: 29 Mar 2007 - 0:00 PDT
Researchers at the Medical University of South Carolina (MUSC) have announced the results of a two-year study, which tested the long-term antidepressant response to VNS (Vagus Nerve Stimulation) TherapyTM in patients with treatment-resistant depression (TRD). The study, of which Mark S. George, M.D., MUSC Distinguished Professor of Psychiatry, Radiology and Neurosciences is a lead author, is expected to appear in the April 2007 issue of the International Journal of Neuropsychopharmacology. Results showed that, of the patients who responded to VNS Therapy, either early or later in treatment, the majority continued to experience significant clinical benefit for up to 24 months. VNS Therapy is the first and only treatment for TRD to demonstrate such long-term improvements.
Patients included in this study, led by Harold A. Sackeim, PhD, of Columbia University, experienced severe chronic depression which proved to be treatment-resistant. The study participants had a 50 percent improvement in their depressive symptoms at either three months or a year after being treated with VNS Therapy. Between 61 percent and 79 percent of these patients sustained this response for 24 months. The durability of response was not attributable to alterations in other treatments.
"These data showing durability of response with VNS Therapy are pretty remarkable under any circumstances, but particularly for the patient population studied here," said George. "Patients with TRD don't respond to medications, and even when they do, they often develop tolerance after 6 months, and the depression returns. These findings regarding long-term sustained effectiveness are very encouraging for psychiatrists and patients with treatment-resistant depression. This study analysis provides additional confirmation that, at least for some patients, the benefits of VNS Therapy for TRD are long-term and improve over time."
Many people with major depression relapse frequently, often despite numerous other treatment trials. More than 40 percent of patients experience a recurrence after two years and more than 60 percent experience recurrence after five years. Eighty percent to 90 percent of those patients having experienced two or more episodes of depression will have additional episodes. Electroconvulsive therapy (ECT) is considered by many psychiatrists as the most effective acute intervention for TRD. However, the majority of TRD patients relapse during the first year following response to ECT. This study shows that VNS Therapy is an effective long-term treatment option for some of these patients.
The FDA approved VNS Therapy as an adjunctive long-term treatment of chronic or recurrent depression for patients 18 years of age or older who are experiencing a major depressive episode and have not had an adequate response to four or more adequate antidepressant treatments. VNS Therapy is also FDA-approved as an adjunctive therapy used to reduce the frequency of seizures in adults and adolescents over 12 years of age with partial onset seizures that are refractory to antiepileptic medications. In addition to treatment-resistant depression and pharmacoresistant epilepsy indications, VNS Therapy is at various stages of research as potential treatments for anxiety disorders, Alzheimer's disease, bulimia, chronic headache/migraine and morbid obesity. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 MUSC Research Offers Hope For Those Resistant To Depression Treatment
顽固性抑郁症治疗新希望
Article Date: 29 Mar 2007 - 0:00 PDT
发表日期: 美国太平洋时间 2007年3月29日 0:00
Researchers at the Medical University of South Carolina (MUSC) have announced the results of a two-year study, which tested the long-term antidepressant response to VNS (Vagus Nerve Stimulation) Therapy TM in patients with treatment-resistant depression (TRD). The study, of which Mark S. George, M.D., MUSC Distinguished Professor of Psychiatry, Radiology and Neurosciences is a lead author, is expected to appear in the April 2007 issue of the International Journal of Neuropsychopharmacology. Results showed that, of the patients who responded to VNS Therapy, either early or later in treatment, the majority continued to experience significant clinical benefit for up to 24 months. VNS Therapy is the first and only treatment for TRD to demonstrate such long-term improvements.
南卡罗来纳医科大学研究者宣布了一个为期2年的研究结果，这项研究证实了迷走神经对顽固性抑郁症患者的长期抗抑郁作用。这项由南卡罗来纳医科大学著名精神病学、放射学和神经学家作为主要作者的研究将在《神经精神药理学杂志》2007年4月刊上发表。研究结果表明那些对迷走神经刺激有效的患者，不论是在早期还是后期治疗，大多数有明显临床缓解效果可持续24个月以上。迷走神经刺激疗法是第一个而且是唯一的证明对顽固性抑郁症有如此长时间改善作用的治疗方法。
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作者:admin@医学,生命科学 2011-03-13 05:11
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