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【文摘发布】台湾接种乙肝疫苗20年后，大学新生
Author: Chang HC, Yen CJ, Lee YC, Chiu TY, Jan CF.
Sourse: J Formos Med Assoc. 2007 Jul;106(7):513-9.
Background/Purpose: The nationwide hepatitis B vaccination program in Taiwan was well known for its efficacy in reducing the carrier rate of hepatitis B and the morbidity and mortality of hepatitis B-related diseases among children. The aim of this study was to investigate the seroprevalence of hepatitis B 20 years after this program was implemented. Methods: A total of 7592 freshmen from one university in Northern Taiwan participated in this study during their school entry health exam in September 2003 and September 2004. Basic data including gender, birthday, family history and vaccination history of hepatitis B by self-reported questionnaire were collected. Hepatitis B serum markers, including hepatitis B surface antigen, antibody against hepatitis B surface antigen, and antibody against hepatitis B core antigen were all checked. The differences in the seroprevalence of hepatitis B between two groups of subjects born before July 1984 and after July 1984 were examined. Multiple logistic analyses were performed for identifying the odds ratio (OR) of family history and other variables for each hepatitis B serum marker. Results: Subjects born after July 1984 were found to have a lower rate of hepatitis B surface antigen of 2.2% (95% confidence interval [CI], 1.8-2.6%) vs. 7.4% (95% CI, 5.9-8.9%), and core antibody against hepatitis B of 6.7% (95% CI, 6.0-7.3%) vs. 23.5% (95% CI, 21.1-25.9%), but a higher rate of surface antibody against hepatitis B of 74.3% (95% CI, 73.2-75.4%) vs. 69.1% (95% CI, 66.5-71.7%) compared with those born before July 1984 (all p < 0.001). Subjects with a family history of hepatitis B had higher risk of being infected by hepatitis B (OR, 4.07; 95% CI, 3.18-5.12) and becoming carriers (OR, 7.26; 95% CI, 5.05-10.44) after adjustment for sex, age, birth year, and self-reported hepatitis B vaccination history. Conclusion: The seroprevalence of hepatitis B surface antigen continued to decline 20 years after neonatal hepatitis B vaccination program. It is strongly recommended that those who have a family history of hepatitis B should receive early check-up of hepatitis B status after complete vaccination or closely follow up their hepatitis B status after neonatal hepatitis B vaccination.
PMID: 17660140 Background/Purpose: The nationwide hepatitis B vaccination program in Taiwan was well known for its efficacy in reducing the carrier rate of hepatitis B and the morbidity and mortality of hepatitis B-related diseases among children.
背景/目的：台湾全地区性的乙肝疫苗计划因其有效的减少了儿童乙肝携带率和乙肝相关性疾病的发病率和死亡率而广为人知。The aim of this study was to investigate the seroprevalence of hepatitis B 20 years after this program implemented. 这项研究的目的是在这项计划实施20年后调查乙肝的血清流行情况。Methods: A total of 7592 freshmen from one university in Northern Taiwan participated in this study during their school entry health exam 方法：共通过入学体检入选北台湾一所大学的7592名新生。in September 2003 and September 2004. Basic data including gender, birthday, family history and vaccination history of hepatitis B by self-reported questionnaire were collected. Hepatitis B serum markers, including hepatitis B surface antigen, antibody against hepatitis B surface antigen, and antibody against hepatitis B core antigen were all checked. 在2003年9月和2004年9月，基本资料已通过自我问卷收集，包括性别，出生日期，家族史，乙肝接种史。乙肝血清标志物，包括HBsAg,anti-HBsAb,anti-HBcAb。The differences in the seroprevalence of hepatitis B between two groups of subjects born before July 1984 and after July 1984 were examined. 观察1984年7月前出生和1984年7月后出生两组新生的乙肝血清学特征差别。Multiple logistic analyses were performed for identifying the odds ratio (OR) of family history and other variables for each hepatitis B serum marker.多因素logistic分析乙肝血清标志物与家族史和其他变量的比值比（OR）。 Results: Subjects born after July 1984 were found to have a lower rate of hepatitis B surface antigen of 2.2% (95% confidence interval [CI], 1.8-2.6%) vs. 7.4% (95% CI, 5.9-8.9%), and core antibody against hepatitis B of 6.7% (95% CI, 6.0-7.3%) vs. 23.5% (95% CI, 21.1-25.9%), but a higher rate of surface antibody against hepatitis B of 74.3% (95% CI, 73.2-75.4%) vs. 69.1% (95% CI, 66.5-71.7%) compared with those born before July 1984 (all p < 0.001). Subjects with a family history of hepatitis B had higher risk of being infected by hepatitis B (OR, 4.07; 95% CI, 3.18-5.12) and becoming carriers (OR, 7.26; 95% CI, 5.05-10.44) after adjustment for sex, age, birth year, and self-reported hepatitis B vaccination history. 结果：1984年7月后出生组的乙肝表面抗原阳性率更低，2.2% (95% 可信区间[CI], 1.8-2.6%) ，1984年7月前出生组 7.4% (95% CI, 5.9-8.9%)。两组的核心抗体阳性率（1984年7月后：1984年7月前)分别是6.7% (95% CI, 6.0-7.3%) vs. 23.5% (95% CI, 21.1-25.9%),乙肝表面抗体是74.3% (95% CI, 73.2-75.4%) vs. 69.1% (95% CI, 66.5-71.7%)(p < 0.001)。Conclusion: The seroprevalence of hepatitis B surface antigen continued to decline 20 years after neonatal hepatitis B vaccination program. It is strongly recommended that those who have a family history of hepatitis B should receive early check-up of hepatitis B status after complete vaccination or closely follow up their hepatitis B status after neonatal hepatitis B vaccination结论：新生儿乙肝免疫计划20年来，乙肝表面抗原的血清流行持续下降。强烈推荐有乙肝家族史的已完成免疫计划者接受早期检查或新生儿免疫后予密切随访。 背景/目的：台湾全地区性的乙肝疫苗计划因其有效的减少了儿童乙肝携带率和乙肝相关性疾病的发病率和死亡率而广为人知。 这项研究的目的是在这项计划实施20年后调查乙肝的血清流行情况。方法：共通过入学体检入选北台湾一所大学的7592名新生。在2003年9月和2004年9月，基本资料已通过自我问卷收集，包括性别，出生日期，家族史，乙肝接种史。乙肝血清标志物，包括HBsAg,anti-HBsAb,anti-HBcAb。观察1984年7月前出生和1984年7月后出生两组新生的乙肝血清学特征差别。多因素logistic分析乙肝血清标志物与家族史和其他变量的比值比（OR）。 结果：1984年7月后出生组的乙肝表面抗原阳性率更低，2.2% (95% 可信区间[CI], 1.8-2.6%) ，1984年7月前出生组 7.4% (95% CI, 5.9-8.9%)。两组的核心抗体阳性率（1984年7月后：1984年7月前)分别是6.7% (95% CI, 6.0-7.3%) vs. 23.5% (95% CI, 21.1-25.9%),乙肝表面抗体是74.3% (95% CI, 73.2-75.4%) vs. 69.1% (95% CI, 66.5-71.7%)(p < 0.001)。对性别，年龄和自我报告的乙肝接种史等因素校正后，发现有乙肝家族史的新生有更高的感染几率（OR, 4.07; 95% CI, 3.18-5.12)和成为携带者的几率（OR, 7.26; 95% CI, 5.05-10.44)。（结论：新生儿乙肝免疫计划20年来，乙肝表面抗原的血清流行持续下降。强烈推荐有乙肝家族史的已完成免疫计划者接受早期检查或新生儿免疫后予密切随访。 文摘类新闻编译格式见：
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作者:admin@医学,生命科学 2011-04-07 05:11
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