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【medical-news】Ovarian cancer more aggressive in obese wom
Sarah Boseley, health editor
Tuesday August 29, 2006
The Guardian
Obese women are less likely to survive ovarian cancer than those of normal weight, according to research published yesterday.
The disease is one of cancer's most lethal forms. Most women who develop it are not diagnosed until the disease is advanced and 70% die within five years.
The paper, published by the American Cancer Society's journal Cancer, suggests for the first time that a woman's weight can affect the course of the disease. Those who are obese, it says, not only have lower survival rates, but the cancer recurs sooner after treatment and they face an earlier death than women who are diagnosed at their ideal body weight.
"This study is the first to identify weight as an independent factor in ovarian cancer in disease progression and overall survival, suggesting that there is an element in the fat tissue itself that influences the outcome of this disease in obese women," said Andrew Li, the study's principal investigator at the Cedars-Sinai Women's Cancer Research Institute in Los Angeles.
Nearly 7,000 cases of ovarian cancer were diagnosed in the UK in 2002. The vast majority, 85%, were in women aged over 50. In 2004 there were 4,434 deaths, according to Cancer Research UK. The US and northern Europe have the highest ovarian cancer rates in the world.
Rising obesity rates in the US, the UK and northern Europe are a major cause of concern, but while the impact on heart disease and diabetes is well known, fewer people understand that being overweight affects their chances of surviving cancer.
Previous studies have shown obesity affects both development and progression of breast, uterine and colorectal cancers, but the nature of the relationship in ovarian cancer has been less well understood. In this study, doctors compared the progression of the disease in 216 women, 35 of whom were obese, while 108 were of ideal weight. The researchers discovered that in addition to their findings on mortality and recurrence of the disease, the cells of the tumours appeared different.
"While further molecular studies are warranted, our study suggests that fat tissue excretes a hormone or protein that causes ovarian cancer cells to grow more aggressively," said Dr Li. "The next steps will be to examine this relationship more closely, and to determine the exact biological mechanisms that influence tumour growth in ovarian cancer."
研究显示肥胖妇女的卵巢癌更严重
据昨天发表的研究，卵巢癌患者中肥胖妇女比正常体重的妇女存活率要低。
卵巢癌是一种致死性的癌症，大多数患者都不能在早期发现诊断，70% 在5年内死亡。
美国癌症协会的杂志Cancer发表的这篇文章首次提出妇女的体重会影响卵巢癌的病程，那些肥胖的患者与理想体重的患者相比不仅存活率较低，而且癌症在治疗后复发的更快因此死亡更早。
该研究的主要负责人、洛杉矶Cedars-Sinai妇女癌症研究所的Andrew Li 说：“这项研究首次提出了体重是卵巢癌病程进展和总生存数的独立影响因素，这提示肥胖妇女的脂肪组织本身可能含有某种成分会影响本病的预后。”
2002年在英国诊断了大约7000例卵巢癌，其中85%是50岁以上的妇女，据英国癌症研究结果2004年有4434例死亡。美国和北欧是世界上卵巢癌发生率最高的地区。
在美国、英国和北欧，不断升高的肥胖率已经引起人们的忧虑，众所周知其对心脏病和糖尿病的影响，但很少人知道体重超重会影响癌症的存活。
以前有研究显示肥胖会影响乳腺、子宫和结肠直肠癌的发生和发展，但大家还不清楚卵巢癌和肥胖之间的关系，这项研究中，医生比较了216例妇女卵巢癌的发展，其中35例为肥胖，108例为理想体重。研究者发现不仅死亡率和复发率不同，肿瘤的细胞也不同。
“我们的研究提示脂肪组织分泌一种激素或蛋白质使卵巢癌的细胞生长更迅速，但这还需要进一步的分子研究，” Li说：“以后我们会更深入的研究这两者之间的关系，并确定其影响卵巢癌肿瘤细胞生长的具体生物学机制。” [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-03-14 17:12
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